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Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
BACKGROUND: An adverse hematological interaction between vitamins E and K has been reported, primarily in patients on anticoagulants. However, little is known regarding circulating levels or tissue concentrations of vitamin K in response to vitamin E supplementation. The purpose of this study was to...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/ https://www.ncbi.nlm.nih.gov/pubmed/16857056 http://dx.doi.org/10.1186/1743-7075-3-29 |
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author | Tovar, Alison Ameho, Clement K Blumberg, Jeffrey B Peterson, James W Smith, Donald Booth, Sarah L |
author_facet | Tovar, Alison Ameho, Clement K Blumberg, Jeffrey B Peterson, James W Smith, Donald Booth, Sarah L |
author_sort | Tovar, Alison |
collection | PubMed |
description | BACKGROUND: An adverse hematological interaction between vitamins E and K has been reported, primarily in patients on anticoagulants. However, little is known regarding circulating levels or tissue concentrations of vitamin K in response to vitamin E supplementation. The purpose of this study was to examine the effect of different levels of dietary α-tocopherol on phylloquinone and menaquinone-4 concentrations, while maintaining a constant intake of phylloquinone, in rat tissues. METHODS: Male 4-wk old Fischer 344 rats (n = 33) were fed one of 3 diets for 12 wk: control (n = 13) with 30 mg all-rac-α-tocopherol acetate/kg diet; vitamin E-supplemented (n = 10) with 100 mg all-rac-α-tocopherol acetate/kg diet; and vitamin E-restricted (n = 10) with <10 mg total tocopherols/kg diet. All 3 diets contained 470 ± 80 μg phylloquinone/kg diet. RESULTS: Phylloquinone concentrations were lower (P ≤ 0.05) in the vitamin E-supplemented compared to the vitamin E-restricted group (mean ± SD spleen: 531 ± 58 vs.735 ± 77; kidney: 20 ± 17 vs. 94 ± 31, brain: 53 ± 19 vs.136 ± 97 pmol/g protein respectively); no statistically significant differences between groups were found in plasma, liver or testis. Similar results were noted with menaquinone-4 concentrations in response to vitamin E supplementation. CONCLUSION: There appears to be a tissue-specific interaction between vitamins E and K when vitamin E is supplemented in rat diets. Future research is required to elucidate the mechanism for this nutrient-nutrient interaction. |
format | Text |
id | pubmed-1544331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15443312006-08-16 Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet Tovar, Alison Ameho, Clement K Blumberg, Jeffrey B Peterson, James W Smith, Donald Booth, Sarah L Nutr Metab (Lond) Research BACKGROUND: An adverse hematological interaction between vitamins E and K has been reported, primarily in patients on anticoagulants. However, little is known regarding circulating levels or tissue concentrations of vitamin K in response to vitamin E supplementation. The purpose of this study was to examine the effect of different levels of dietary α-tocopherol on phylloquinone and menaquinone-4 concentrations, while maintaining a constant intake of phylloquinone, in rat tissues. METHODS: Male 4-wk old Fischer 344 rats (n = 33) were fed one of 3 diets for 12 wk: control (n = 13) with 30 mg all-rac-α-tocopherol acetate/kg diet; vitamin E-supplemented (n = 10) with 100 mg all-rac-α-tocopherol acetate/kg diet; and vitamin E-restricted (n = 10) with <10 mg total tocopherols/kg diet. All 3 diets contained 470 ± 80 μg phylloquinone/kg diet. RESULTS: Phylloquinone concentrations were lower (P ≤ 0.05) in the vitamin E-supplemented compared to the vitamin E-restricted group (mean ± SD spleen: 531 ± 58 vs.735 ± 77; kidney: 20 ± 17 vs. 94 ± 31, brain: 53 ± 19 vs.136 ± 97 pmol/g protein respectively); no statistically significant differences between groups were found in plasma, liver or testis. Similar results were noted with menaquinone-4 concentrations in response to vitamin E supplementation. CONCLUSION: There appears to be a tissue-specific interaction between vitamins E and K when vitamin E is supplemented in rat diets. Future research is required to elucidate the mechanism for this nutrient-nutrient interaction. BioMed Central 2006-07-20 /pmc/articles/PMC1544331/ /pubmed/16857056 http://dx.doi.org/10.1186/1743-7075-3-29 Text en Copyright © 2006 Tovar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Tovar, Alison Ameho, Clement K Blumberg, Jeffrey B Peterson, James W Smith, Donald Booth, Sarah L Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title | Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title_full | Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title_fullStr | Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title_full_unstemmed | Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title_short | Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet |
title_sort | extrahepatic tissue concentrations of vitamin k are lower in rats fed a high vitamin e diet |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/ https://www.ncbi.nlm.nih.gov/pubmed/16857056 http://dx.doi.org/10.1186/1743-7075-3-29 |
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