Statistical tests for differential expression in cDNA microarray experiments

Extracting biological information from microarray data requires appropriate statistical methods. The simplest statistical method for detecting differential expression is the t test, which can be used to compare two conditions when there is replication of samples. With more than two conditions, analy...

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Detalles Bibliográficos
Autores principales: Cui, Xiangqin, Churchill, Gary A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154570/
https://www.ncbi.nlm.nih.gov/pubmed/12702200
http://dx.doi.org/10.1186/gb-2003-4-4-210
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author Cui, Xiangqin
Churchill, Gary A
author_facet Cui, Xiangqin
Churchill, Gary A
author_sort Cui, Xiangqin
collection PubMed
description Extracting biological information from microarray data requires appropriate statistical methods. The simplest statistical method for detecting differential expression is the t test, which can be used to compare two conditions when there is replication of samples. With more than two conditions, analysis of variance (ANOVA) can be used, and the mixed ANOVA model is a general and powerful approach for microarray experiments with multiple factors and/or several sources of variation.
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spelling pubmed-1545702003-05-08 Statistical tests for differential expression in cDNA microarray experiments Cui, Xiangqin Churchill, Gary A Genome Biol Review Extracting biological information from microarray data requires appropriate statistical methods. The simplest statistical method for detecting differential expression is the t test, which can be used to compare two conditions when there is replication of samples. With more than two conditions, analysis of variance (ANOVA) can be used, and the mixed ANOVA model is a general and powerful approach for microarray experiments with multiple factors and/or several sources of variation. BioMed Central 2003 2003-03-17 /pmc/articles/PMC154570/ /pubmed/12702200 http://dx.doi.org/10.1186/gb-2003-4-4-210 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Review
Cui, Xiangqin
Churchill, Gary A
Statistical tests for differential expression in cDNA microarray experiments
title Statistical tests for differential expression in cDNA microarray experiments
title_full Statistical tests for differential expression in cDNA microarray experiments
title_fullStr Statistical tests for differential expression in cDNA microarray experiments
title_full_unstemmed Statistical tests for differential expression in cDNA microarray experiments
title_short Statistical tests for differential expression in cDNA microarray experiments
title_sort statistical tests for differential expression in cdna microarray experiments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154570/
https://www.ncbi.nlm.nih.gov/pubmed/12702200
http://dx.doi.org/10.1186/gb-2003-4-4-210
work_keys_str_mv AT cuixiangqin statisticaltestsfordifferentialexpressionincdnamicroarrayexperiments
AT churchillgarya statisticaltestsfordifferentialexpressionincdnamicroarrayexperiments

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