Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-κB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

L-acetylcarnitine (LAC), a drug utilized for the treatment of neuropathic pain in humans, has been shown to induce analgesia in rodents by up-regulating the expression of metabotropic glutamate receptor 2 (mGlu2) in dorsal root ganglia (DRG). We now report that LAC-induced upregulation of mGlu2 expr...

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Detalles Bibliográficos
Autores principales: Chiechio, Santina, Copani, Agata, De Petris, Laura, Morales, Maria Elena P, Nicoletti, Ferdinando, Gereau, Robert W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550235/
https://www.ncbi.nlm.nih.gov/pubmed/16764720
http://dx.doi.org/10.1186/1744-8069-2-20

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