Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands

BACKGROUND: G-protein-coupled receptors (GPCRs) play a crucial role in many biological processes and represent a major class of drug targets. However, purification of GPCRs for biochemical study is difficult and current methods of studying receptor-ligand interactions involve in vitro systems. Caeno...

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Detalles Bibliográficos
Autores principales: Teng, Michelle S, Dekkers, Martijn PJ, Ng, Bee Ling, Rademakers, Suzanne, Jansen, Gert, Fraser, Andrew G, McCafferty, John
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550261/
https://www.ncbi.nlm.nih.gov/pubmed/16857046
http://dx.doi.org/10.1186/1741-7007-4-22

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