KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific...

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Autores principales: Qi, Ying, Martin, Maureen P, Gao, Xiaojiang, Jacobson, Lisa, Goedert, James J, Buchbinder, Susan, Kirk, Gregory D, O'Brien, Stephen J, Trowsdale, John, Carrington, Mary
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550271/
https://www.ncbi.nlm.nih.gov/pubmed/16933987
http://dx.doi.org/10.1371/journal.ppat.0020079
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author Qi, Ying
Martin, Maureen P
Gao, Xiaojiang
Jacobson, Lisa
Goedert, James J
Buchbinder, Susan
Kirk, Gregory D
O'Brien, Stephen J
Trowsdale, John
Carrington, Mary
author_facet Qi, Ying
Martin, Maureen P
Gao, Xiaojiang
Jacobson, Lisa
Goedert, James J
Buchbinder, Susan
Kirk, Gregory D
O'Brien, Stephen J
Trowsdale, John
Carrington, Mary
author_sort Qi, Ying
collection PubMed
description The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
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spelling pubmed-15502712006-09-07 KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections Qi, Ying Martin, Maureen P Gao, Xiaojiang Jacobson, Lisa Goedert, James J Buchbinder, Susan Kirk, Gregory D O'Brien, Stephen J Trowsdale, John Carrington, Mary PLoS Pathog Research Article The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS. Public Library of Science 2006-08 2006-08-18 /pmc/articles/PMC1550271/ /pubmed/16933987 http://dx.doi.org/10.1371/journal.ppat.0020079 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Qi, Ying
Martin, Maureen P
Gao, Xiaojiang
Jacobson, Lisa
Goedert, James J
Buchbinder, Susan
Kirk, Gregory D
O'Brien, Stephen J
Trowsdale, John
Carrington, Mary
KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title_full KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title_fullStr KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title_full_unstemmed KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title_short KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
title_sort kir/hla pleiotropism: protection against both hiv and opportunistic infections
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550271/
https://www.ncbi.nlm.nih.gov/pubmed/16933987
http://dx.doi.org/10.1371/journal.ppat.0020079
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