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Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes
Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymer...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550386/ https://www.ncbi.nlm.nih.gov/pubmed/16792804 http://dx.doi.org/10.1186/1747-1028-1-12 |
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author | Crasta, Karen Surana, Uttam |
author_facet | Crasta, Karen Surana, Uttam |
author_sort | Crasta, Karen |
collection | PubMed |
description | Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase. |
format | Text |
id | pubmed-1550386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15503862006-08-18 Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes Crasta, Karen Surana, Uttam Cell Div Review Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase. BioMed Central 2006-06-22 /pmc/articles/PMC1550386/ /pubmed/16792804 http://dx.doi.org/10.1186/1747-1028-1-12 Text en Copyright © 2006 Crasta and Surana; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Crasta, Karen Surana, Uttam Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title | Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title_full | Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title_fullStr | Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title_full_unstemmed | Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title_short | Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes |
title_sort | disjunction of conjoined twins: cdk1, cdh1 and separation of centrosomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550386/ https://www.ncbi.nlm.nih.gov/pubmed/16792804 http://dx.doi.org/10.1186/1747-1028-1-12 |
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