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Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus
BACKGROUND: Methicillin-resistant S. aureus (MRSA) with low susceptibility to glycopeptides is uncommon. CASE PRESENTATION: The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550409/ https://www.ncbi.nlm.nih.gov/pubmed/16872491 http://dx.doi.org/10.1186/1471-2334-6-124 |
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author | Chesi, Giuseppe Colli, Andrea Mestres, Carlos A Gambarati, Gianpaolo Boni, Fabrizio Gherli, Tiziano |
author_facet | Chesi, Giuseppe Colli, Andrea Mestres, Carlos A Gambarati, Gianpaolo Boni, Fabrizio Gherli, Tiziano |
author_sort | Chesi, Giuseppe |
collection | PubMed |
description | BACKGROUND: Methicillin-resistant S. aureus (MRSA) with low susceptibility to glycopeptides is uncommon. CASE PRESENTATION: The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There was response only to quinupristin/dalfopristin. He had a motorcycling accident four years before undergoing right above-the-knee amputation and orthopaedic fixation of the left limb. There were multiple episodes of left MRSA-osteomyelitis controlled after surgery and vancomycin therapy. MRSA isolated from the blood at the time of IE presented with the same profile than the isolated four years earlier. Sequential treatment with teicoplanin-cotrimoxazole and Linezolid associated to vancomycin – rifampicin – cotrimoxazole had no improvement. Infection was controlled after 28 days of therapy with quinupristin/dalfopristin. CONCLUSION: The literature presents only a few cases of MRSA IE not susceptible to glycopeptides in not drug addicted patients. This case shows the comparison of a highly-resistant MRSA after previous S. aureus osteomyelitis treated with glycopeptides. This is the first description of successful treatment of resistant-MRSA IE of the tricuspid valve complicated by multiple pulmonary septic infarction with quinupristin/dalfopristin |
format | Text |
id | pubmed-1550409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15504092006-08-18 Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus Chesi, Giuseppe Colli, Andrea Mestres, Carlos A Gambarati, Gianpaolo Boni, Fabrizio Gherli, Tiziano BMC Infect Dis Case Report BACKGROUND: Methicillin-resistant S. aureus (MRSA) with low susceptibility to glycopeptides is uncommon. CASE PRESENTATION: The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There was response only to quinupristin/dalfopristin. He had a motorcycling accident four years before undergoing right above-the-knee amputation and orthopaedic fixation of the left limb. There were multiple episodes of left MRSA-osteomyelitis controlled after surgery and vancomycin therapy. MRSA isolated from the blood at the time of IE presented with the same profile than the isolated four years earlier. Sequential treatment with teicoplanin-cotrimoxazole and Linezolid associated to vancomycin – rifampicin – cotrimoxazole had no improvement. Infection was controlled after 28 days of therapy with quinupristin/dalfopristin. CONCLUSION: The literature presents only a few cases of MRSA IE not susceptible to glycopeptides in not drug addicted patients. This case shows the comparison of a highly-resistant MRSA after previous S. aureus osteomyelitis treated with glycopeptides. This is the first description of successful treatment of resistant-MRSA IE of the tricuspid valve complicated by multiple pulmonary septic infarction with quinupristin/dalfopristin BioMed Central 2006-07-26 /pmc/articles/PMC1550409/ /pubmed/16872491 http://dx.doi.org/10.1186/1471-2334-6-124 Text en Copyright © 2006 Chesi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Chesi, Giuseppe Colli, Andrea Mestres, Carlos A Gambarati, Gianpaolo Boni, Fabrizio Gherli, Tiziano Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title_full | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title_fullStr | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title_full_unstemmed | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title_short | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
title_sort | multiresistant-mrsa tricuspid valve infective endocarditis with ancient osteomyelitis locus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550409/ https://www.ncbi.nlm.nih.gov/pubmed/16872491 http://dx.doi.org/10.1186/1471-2334-6-124 |
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