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Macrophage migration inhibitory factor: controller of systemic inflammation

Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome...

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Detalles Bibliográficos
Autores principales: Larson, Douglas F, Horak, Katherine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550887/
https://www.ncbi.nlm.nih.gov/pubmed/16677407
http://dx.doi.org/10.1186/cc4899
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author Larson, Douglas F
Horak, Katherine
author_facet Larson, Douglas F
Horak, Katherine
author_sort Larson, Douglas F
collection PubMed
description Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.
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spelling pubmed-15508872006-08-22 Macrophage migration inhibitory factor: controller of systemic inflammation Larson, Douglas F Horak, Katherine Crit Care Commentary Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function. BioMed Central 2006 2006-04-06 /pmc/articles/PMC1550887/ /pubmed/16677407 http://dx.doi.org/10.1186/cc4899 Text en Copyright © 2006 BioMed Central Ltd
spellingShingle Commentary
Larson, Douglas F
Horak, Katherine
Macrophage migration inhibitory factor: controller of systemic inflammation
title Macrophage migration inhibitory factor: controller of systemic inflammation
title_full Macrophage migration inhibitory factor: controller of systemic inflammation
title_fullStr Macrophage migration inhibitory factor: controller of systemic inflammation
title_full_unstemmed Macrophage migration inhibitory factor: controller of systemic inflammation
title_short Macrophage migration inhibitory factor: controller of systemic inflammation
title_sort macrophage migration inhibitory factor: controller of systemic inflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550887/
https://www.ncbi.nlm.nih.gov/pubmed/16677407
http://dx.doi.org/10.1186/cc4899
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