The struggle to detect circulating DNA

In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performe...

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Detalles Bibliográficos
Autor principal: Zeerleder, Sacha
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550959/
https://www.ncbi.nlm.nih.gov/pubmed/16719935
http://dx.doi.org/10.1186/cc4932
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author Zeerleder, Sacha
author_facet Zeerleder, Sacha
author_sort Zeerleder, Sacha
collection PubMed
description In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performed by real-time quantitative PCR or immunological methods such as ELISA. The diagnostic value of both methods can be impaired by inappropriate handling of the samples. Assessment of circulating DNA in patients admitted to the intensive care unit offers a tool for predicting morbidity and mortality.
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spelling pubmed-15509592006-08-22 The struggle to detect circulating DNA Zeerleder, Sacha Crit Care Commentary In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performed by real-time quantitative PCR or immunological methods such as ELISA. The diagnostic value of both methods can be impaired by inappropriate handling of the samples. Assessment of circulating DNA in patients admitted to the intensive care unit offers a tool for predicting morbidity and mortality. BioMed Central 2006 2006-05-16 /pmc/articles/PMC1550959/ /pubmed/16719935 http://dx.doi.org/10.1186/cc4932 Text en Copyright © 2006 BioMed Central Ltd
spellingShingle Commentary
Zeerleder, Sacha
The struggle to detect circulating DNA
title The struggle to detect circulating DNA
title_full The struggle to detect circulating DNA
title_fullStr The struggle to detect circulating DNA
title_full_unstemmed The struggle to detect circulating DNA
title_short The struggle to detect circulating DNA
title_sort struggle to detect circulating dna
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550959/
https://www.ncbi.nlm.nih.gov/pubmed/16719935
http://dx.doi.org/10.1186/cc4932
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AT zeerledersacha struggletodetectcirculatingdna

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