Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol

BACKGROUND: Trichloroethylene (TCE) is a suspected human carcinogen and a common ground-water contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. CH is metabolized to the hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase (ALDH)...

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Detalles Bibliográficos
Autores principales: Bronley-DeLancey, Apryl, McMillan, David C., McMillan, JoEllyn M., Jollow, David J., Mohr, Lawrence C., Hoel, David G.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1551986/
https://www.ncbi.nlm.nih.gov/pubmed/16882532
http://dx.doi.org/10.1289/ehp.9047

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