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SNFing HIV transcription
The SWI/SNF chromatin remodeling complex is an essential regulator of transcription of cellular genes. HIV-1 infection induces exit of a core component of SWI/SNF, Ini1, into the cytoplasm and its association with the viral pre-integration complex. Several recent papers published in EMBO Journal, Jo...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555607/ https://www.ncbi.nlm.nih.gov/pubmed/16899112 http://dx.doi.org/10.1186/1742-4690-3-49 |
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| author | Bukrinsky, Michael |
| author_facet | Bukrinsky, Michael |
| author_sort | Bukrinsky, Michael |
| collection | PubMed |
| description | The SWI/SNF chromatin remodeling complex is an essential regulator of transcription of cellular genes. HIV-1 infection induces exit of a core component of SWI/SNF, Ini1, into the cytoplasm and its association with the viral pre-integration complex. Several recent papers published in EMBO Journal, Journal of Biological Chemistry, and Retrovirology provide new information regarding possible functions of Ini1 and SWI/SNF in HIV life cycle. It appears that Ini1 has an inhibitory effect on pre-integration steps of HIV replication, but also contributes to stimulation of Tat-mediated transcription. This stimulation involves displacement of the nucleosome positioned at the HIV promoter. |
| format | Text |
| id | pubmed-1555607 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2006 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-15556072006-08-26 SNFing HIV transcription Bukrinsky, Michael Retrovirology Commentary The SWI/SNF chromatin remodeling complex is an essential regulator of transcription of cellular genes. HIV-1 infection induces exit of a core component of SWI/SNF, Ini1, into the cytoplasm and its association with the viral pre-integration complex. Several recent papers published in EMBO Journal, Journal of Biological Chemistry, and Retrovirology provide new information regarding possible functions of Ini1 and SWI/SNF in HIV life cycle. It appears that Ini1 has an inhibitory effect on pre-integration steps of HIV replication, but also contributes to stimulation of Tat-mediated transcription. This stimulation involves displacement of the nucleosome positioned at the HIV promoter. BioMed Central 2006-08-09 /pmc/articles/PMC1555607/ /pubmed/16899112 http://dx.doi.org/10.1186/1742-4690-3-49 Text en Copyright © 2006 Bukrinsky; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Commentary Bukrinsky, Michael SNFing HIV transcription |
| title | SNFing HIV transcription |
| title_full | SNFing HIV transcription |
| title_fullStr | SNFing HIV transcription |
| title_full_unstemmed | SNFing HIV transcription |
| title_short | SNFing HIV transcription |
| title_sort | snfing hiv transcription |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555607/ https://www.ncbi.nlm.nih.gov/pubmed/16899112 http://dx.doi.org/10.1186/1742-4690-3-49 |
| work_keys_str_mv | AT bukrinskymichael snfinghivtranscription |