Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs

BACKGROUND: P-TEFb, a general RNA polymerase II elongation factor, is composed of CDK9 (cyclin-dependent kinase 9) as a catalytic unit and either cyclin T1, T2 or K as a regulatory subunit. The cyclin T1/P-TEFb complex is targeted by HIV to mediate Tat transactivation. Cyclin T1 protein expression i...

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Detalles Bibliográficos
Autores principales: Yu, Wendong, Wang, Yan, Shaw, Chad A, Qin, Xiao-Feng, Rice, Andrew P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557533/
https://www.ncbi.nlm.nih.gov/pubmed/16764723
http://dx.doi.org/10.1186/1742-4690-3-32

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