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Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice
In Arabidopsis, tandemly arrayed genes (TAGs) comprise >10% of the genes in the genome. These duplicated genes represent a rich template for genetic innovation, but little is known of the evolutionary forces governing their generation and maintenance. Here we compare the organization and evolutio...
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557586/ https://www.ncbi.nlm.nih.gov/pubmed/16948529 http://dx.doi.org/10.1371/journal.pcbi.0020115 |
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author | Rizzon, Carene Ponger, Loic Gaut, Brandon S |
author_facet | Rizzon, Carene Ponger, Loic Gaut, Brandon S |
author_sort | Rizzon, Carene |
collection | PubMed |
description | In Arabidopsis, tandemly arrayed genes (TAGs) comprise >10% of the genes in the genome. These duplicated genes represent a rich template for genetic innovation, but little is known of the evolutionary forces governing their generation and maintenance. Here we compare the organization and evolution of TAGs between Arabidopsis and rice, two plant genomes that diverged ~150 million years ago. TAGs from the two genomes are similar in a number of respects, including the proportion of genes that are tandemly arrayed, the number of genes within an array, the number of tandem arrays, and the dearth of TAGs relative to single copy genes in centromeric regions. Analysis of recombination rates along rice chromosomes confirms a positive correlation between the occurrence of TAGs and recombination rate, as found in Arabidopsis. TAGs are also biased functionally relative to duplicated, nontandemly arrayed genes. In both genomes, TAGs are enriched for genes that encode membrane proteins and function in “abiotic and biotic stress” but underrepresented for genes involved in transcription and DNA or RNA binding functions. We speculate that these observations reflect an evolutionary trend in which successful tandem duplication involves genes either at the end of biochemical pathways or in flexible steps in a pathway, for which fluctuation in copy number is unlikely to affect downstream genes. Despite differences in the age distribution of tandem arrays, the striking similarities between rice and Arabidopsis indicate similar mechanisms of TAG generation and maintenance. |
format | Text |
id | pubmed-1557586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-15575862006-10-02 Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice Rizzon, Carene Ponger, Loic Gaut, Brandon S PLoS Comput Biol Research Article In Arabidopsis, tandemly arrayed genes (TAGs) comprise >10% of the genes in the genome. These duplicated genes represent a rich template for genetic innovation, but little is known of the evolutionary forces governing their generation and maintenance. Here we compare the organization and evolution of TAGs between Arabidopsis and rice, two plant genomes that diverged ~150 million years ago. TAGs from the two genomes are similar in a number of respects, including the proportion of genes that are tandemly arrayed, the number of genes within an array, the number of tandem arrays, and the dearth of TAGs relative to single copy genes in centromeric regions. Analysis of recombination rates along rice chromosomes confirms a positive correlation between the occurrence of TAGs and recombination rate, as found in Arabidopsis. TAGs are also biased functionally relative to duplicated, nontandemly arrayed genes. In both genomes, TAGs are enriched for genes that encode membrane proteins and function in “abiotic and biotic stress” but underrepresented for genes involved in transcription and DNA or RNA binding functions. We speculate that these observations reflect an evolutionary trend in which successful tandem duplication involves genes either at the end of biochemical pathways or in flexible steps in a pathway, for which fluctuation in copy number is unlikely to affect downstream genes. Despite differences in the age distribution of tandem arrays, the striking similarities between rice and Arabidopsis indicate similar mechanisms of TAG generation and maintenance. Public Library of Science 2006-09 2006-09-01 /pmc/articles/PMC1557586/ /pubmed/16948529 http://dx.doi.org/10.1371/journal.pcbi.0020115 Text en © 2006 Rizzon et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Rizzon, Carene Ponger, Loic Gaut, Brandon S Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title | Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title_full | Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title_fullStr | Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title_full_unstemmed | Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title_short | Striking Similarities in the Genomic Distribution of Tandemly Arrayed Genes in Arabidopsis and Rice |
title_sort | striking similarities in the genomic distribution of tandemly arrayed genes in arabidopsis and rice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557586/ https://www.ncbi.nlm.nih.gov/pubmed/16948529 http://dx.doi.org/10.1371/journal.pcbi.0020115 |
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