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Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression

BACKGROUND: Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the formation of prostaglandins. The inducible isoform of COX (COX-2) is highly expressed in aggressive metastatic breast cancers and may play a critical role in cancer progression (i.e. growth and metastasis). However, the...

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Detalles Bibliográficos
Autores principales: Larkins, Teri L, Nowell, Marchele, Singh, Shailesh, Sanford, Gary L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559713/
https://www.ncbi.nlm.nih.gov/pubmed/16831226
http://dx.doi.org/10.1186/1471-2407-6-181