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Signaling, Polyubiquitination, Trafficking, and Inclusions: Sequestosome 1/p62's Role in Neurodegenerative Disease

Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated proteins can be prevented by chaperones, or by targeting their d...

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Detalles Bibliográficos
Autores principales:	Wooten, Marie W., Hu, Xiao, Babu, J. Ramesh, Seibenhener, M. Lamar, Geetha, Thangiah, Paine, Michael G., Wooten, Michael C.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2006
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559922/ https://www.ncbi.nlm.nih.gov/pubmed/17047309 http://dx.doi.org/10.1155/JBB/2006/62079

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