Targeted Delivery of siRNA

Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers seve...

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Detalles Bibliográficos
Autores principales: Oliveira, Sabrina, Storm, Gert, Schiffelers, Raymond M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
https://www.ncbi.nlm.nih.gov/pubmed/17057365
http://dx.doi.org/10.1155/JBB/2006/63675
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author Oliveira, Sabrina
Storm, Gert
Schiffelers, Raymond M.
author_facet Oliveira, Sabrina
Storm, Gert
Schiffelers, Raymond M.
author_sort Oliveira, Sabrina
collection PubMed
description Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies.
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spelling pubmed-15599242006-10-10 Targeted Delivery of siRNA Oliveira, Sabrina Storm, Gert Schiffelers, Raymond M. J Biomed Biotechnol Review Article Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies. Hindawi Publishing Corporation 2006 2006-06-25 /pmc/articles/PMC1559924/ /pubmed/17057365 http://dx.doi.org/10.1155/JBB/2006/63675 Text en Copyright © 2006 Sabrina Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oliveira, Sabrina
Storm, Gert
Schiffelers, Raymond M.
Targeted Delivery of siRNA
title Targeted Delivery of siRNA
title_full Targeted Delivery of siRNA
title_fullStr Targeted Delivery of siRNA
title_full_unstemmed Targeted Delivery of siRNA
title_short Targeted Delivery of siRNA
title_sort targeted delivery of sirna
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
https://www.ncbi.nlm.nih.gov/pubmed/17057365
http://dx.doi.org/10.1155/JBB/2006/63675
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