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36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report
BACKGROUND: Orlistat is an anti-obesity drug licensed in the United Kingdom for 7 years. We present a case of a patient who developed pancreatitis four days after commencing orlistat. CASE PRESENTATION: A 36 year old man presented to hospital with acute severe pancreatitis four days after starting a...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560153/ https://www.ncbi.nlm.nih.gov/pubmed/16938137 http://dx.doi.org/10.1186/1475-2891-5-19 |
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author | Napier, Sarah Thomas, Matthew |
author_facet | Napier, Sarah Thomas, Matthew |
author_sort | Napier, Sarah |
collection | PubMed |
description | BACKGROUND: Orlistat is an anti-obesity drug licensed in the United Kingdom for 7 years. We present a case of a patient who developed pancreatitis four days after commencing orlistat. CASE PRESENTATION: A 36 year old man presented to hospital with acute severe pancreatitis four days after starting a course of Orlistat, a lipase inhibitor used in the treatment of obesity. A diagnosis of drug related pancreatitis was made by exclusion of other causes of pancreatitis; he was a teetotaller, had a normal serum calcium, had no family history of pancreatitis or hyperlipidaemia, no history of trauma and had no evidence of gallstones on Computerised Tomography scan (CT). CONCLUSION: Orlistat was the only drug that had been started recently and has been associated with pancreatitis previously. We found no case reports of similar cases, however 99 cases of orlistat related pancreatitis have been reported to the Food and Drug Administration (FDA), but no causative link has been found in clinical trials by the drug company. It is therefore not on the list of possible complications or side effects of the drug. |
format | Text |
id | pubmed-1560153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15601532006-09-06 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report Napier, Sarah Thomas, Matthew Nutr J Case Report BACKGROUND: Orlistat is an anti-obesity drug licensed in the United Kingdom for 7 years. We present a case of a patient who developed pancreatitis four days after commencing orlistat. CASE PRESENTATION: A 36 year old man presented to hospital with acute severe pancreatitis four days after starting a course of Orlistat, a lipase inhibitor used in the treatment of obesity. A diagnosis of drug related pancreatitis was made by exclusion of other causes of pancreatitis; he was a teetotaller, had a normal serum calcium, had no family history of pancreatitis or hyperlipidaemia, no history of trauma and had no evidence of gallstones on Computerised Tomography scan (CT). CONCLUSION: Orlistat was the only drug that had been started recently and has been associated with pancreatitis previously. We found no case reports of similar cases, however 99 cases of orlistat related pancreatitis have been reported to the Food and Drug Administration (FDA), but no causative link has been found in clinical trials by the drug company. It is therefore not on the list of possible complications or side effects of the drug. BioMed Central 2006-08-28 /pmc/articles/PMC1560153/ /pubmed/16938137 http://dx.doi.org/10.1186/1475-2891-5-19 Text en Copyright © 2006 Napier and Thomas; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Napier, Sarah Thomas, Matthew 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title_full | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title_fullStr | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title_full_unstemmed | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title_short | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
title_sort | 36 year old man presenting with pancreatitis and a history of recent commencement of orlistat case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560153/ https://www.ncbi.nlm.nih.gov/pubmed/16938137 http://dx.doi.org/10.1186/1475-2891-5-19 |
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