Cargando…
Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features
BACKGROUND: Oncocytic carcinoma is an extremely rare neoplasm of the salivary glands. We report a case of oncocytic carcinoma arising in a parotid gland in a 66-year-old female. METHOD: An excisional biopsy of the parotid tumor was performed. The specimen was submitted for histology and after fixati...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564019/ https://www.ncbi.nlm.nih.gov/pubmed/16923179 http://dx.doi.org/10.1186/1477-7819-4-54 |
_version_ | 1782129534759337984 |
---|---|
author | Giordano, Giovanna Gabrielli, Marzio Gnetti, Letizia Ferri, Teore |
author_facet | Giordano, Giovanna Gabrielli, Marzio Gnetti, Letizia Ferri, Teore |
author_sort | Giordano, Giovanna |
collection | PubMed |
description | BACKGROUND: Oncocytic carcinoma is an extremely rare neoplasm of the salivary glands. We report a case of oncocytic carcinoma arising in a parotid gland in a 66-year-old female. METHOD: An excisional biopsy of the parotid tumor was performed. The specimen was submitted for histology and after fixation in formalin solution and inclusion in paraffin, 3–5 μm sections were stained with hematoxylin and eosin for conventional evaluation and Periodic acid Schiff stain. Immunohistochemical studies were performed using antibodies against mitochondrial antigen, keratin, S-100, alpha-actin, vimentin, alpha-1-antichymotrypsin as well as an ultrastructural analysis was performed. RESULTS: Frozen sections revealed an infiltrative growth pattern and the diagnosis of a malignant epithelial lesion was made. Permanent sections stained with haematoxylin and eosin revealed a neoplasm that had replaced a wide area of the parotid gland and had invaded subcutaneous adipose tissue. Perineural invasion was evident, but vascular invasion was not found. Neoplastic elements were large, round or polyhedral cells and were arranged in solid sheets, islands and cords. The cytoplasm was abundant, eosinophilic and finely granular. The nuclei were large and located centrally or peripherally. The nucleoli were distinct and large. Periodic acid Schiff stain demonstrated a granular cytoplasm. Immunohistochemistry demonstrated mithochondrial antigen, keratin, and chymotrypsin immunoreactivity in the neoplastic cells. Ultrastructural analysis revealed numerous mitochondria packed into the cytoplasm of the neoplastic cells. Thus, the final diagnosis was that of oncocytic carcinoma of parotid gland. CONCLUSION: This neoplasm shows clinical, microscopical, histological and ultrastructural features of oncocytic carcinoma and this must be considered in the differential diagnosis of other proliferations in the parotid gland with abundant granular cytoplasm and metastatic oncocytic carcinomas. |
format | Text |
id | pubmed-1564019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15640192006-09-12 Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features Giordano, Giovanna Gabrielli, Marzio Gnetti, Letizia Ferri, Teore World J Surg Oncol Case Report BACKGROUND: Oncocytic carcinoma is an extremely rare neoplasm of the salivary glands. We report a case of oncocytic carcinoma arising in a parotid gland in a 66-year-old female. METHOD: An excisional biopsy of the parotid tumor was performed. The specimen was submitted for histology and after fixation in formalin solution and inclusion in paraffin, 3–5 μm sections were stained with hematoxylin and eosin for conventional evaluation and Periodic acid Schiff stain. Immunohistochemical studies were performed using antibodies against mitochondrial antigen, keratin, S-100, alpha-actin, vimentin, alpha-1-antichymotrypsin as well as an ultrastructural analysis was performed. RESULTS: Frozen sections revealed an infiltrative growth pattern and the diagnosis of a malignant epithelial lesion was made. Permanent sections stained with haematoxylin and eosin revealed a neoplasm that had replaced a wide area of the parotid gland and had invaded subcutaneous adipose tissue. Perineural invasion was evident, but vascular invasion was not found. Neoplastic elements were large, round or polyhedral cells and were arranged in solid sheets, islands and cords. The cytoplasm was abundant, eosinophilic and finely granular. The nuclei were large and located centrally or peripherally. The nucleoli were distinct and large. Periodic acid Schiff stain demonstrated a granular cytoplasm. Immunohistochemistry demonstrated mithochondrial antigen, keratin, and chymotrypsin immunoreactivity in the neoplastic cells. Ultrastructural analysis revealed numerous mitochondria packed into the cytoplasm of the neoplastic cells. Thus, the final diagnosis was that of oncocytic carcinoma of parotid gland. CONCLUSION: This neoplasm shows clinical, microscopical, histological and ultrastructural features of oncocytic carcinoma and this must be considered in the differential diagnosis of other proliferations in the parotid gland with abundant granular cytoplasm and metastatic oncocytic carcinomas. BioMed Central 2006-08-21 /pmc/articles/PMC1564019/ /pubmed/16923179 http://dx.doi.org/10.1186/1477-7819-4-54 Text en Copyright © 2006 Giordano et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Giordano, Giovanna Gabrielli, Marzio Gnetti, Letizia Ferri, Teore Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title | Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title_full | Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title_fullStr | Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title_full_unstemmed | Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title_short | Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
title_sort | oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564019/ https://www.ncbi.nlm.nih.gov/pubmed/16923179 http://dx.doi.org/10.1186/1477-7819-4-54 |
work_keys_str_mv | AT giordanogiovanna oncocyticcarcinomaofparotidglandacasereportwithclinicalimmunohistochemicalandultrastructuralfeatures AT gabriellimarzio oncocyticcarcinomaofparotidglandacasereportwithclinicalimmunohistochemicalandultrastructuralfeatures AT gnettiletizia oncocyticcarcinomaofparotidglandacasereportwithclinicalimmunohistochemicalandultrastructuralfeatures AT ferriteore oncocyticcarcinomaofparotidglandacasereportwithclinicalimmunohistochemicalandultrastructuralfeatures |