Combined histomorphometric and gene-expression profiling applied to toxicology

We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expressio...

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Autores principales: Kriete, Andres, Anderson, Mary K, Love, Brad, Freund, John, Caffrey, James J, Young, M Brook, Sendera, Timothy J, Magnuson, Scott R, Braughler, J Mark
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156588/
https://www.ncbi.nlm.nih.gov/pubmed/12734012
http://dx.doi.org/10.1186/gb-2003-4-5-r32
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author Kriete, Andres
Anderson, Mary K
Love, Brad
Freund, John
Caffrey, James J
Young, M Brook
Sendera, Timothy J
Magnuson, Scott R
Braughler, J Mark
author_facet Kriete, Andres
Anderson, Mary K
Love, Brad
Freund, John
Caffrey, James J
Young, M Brook
Sendera, Timothy J
Magnuson, Scott R
Braughler, J Mark
author_sort Kriete, Andres
collection PubMed
description We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl(4))-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.
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spelling pubmed-1565882003-06-05 Combined histomorphometric and gene-expression profiling applied to toxicology Kriete, Andres Anderson, Mary K Love, Brad Freund, John Caffrey, James J Young, M Brook Sendera, Timothy J Magnuson, Scott R Braughler, J Mark Genome Biol Method We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl(4))-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis. BioMed Central 2003 2003-04-30 /pmc/articles/PMC156588/ /pubmed/12734012 http://dx.doi.org/10.1186/gb-2003-4-5-r32 Text en Copyright © 2003 Kriete et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying andredistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL
spellingShingle Method
Kriete, Andres
Anderson, Mary K
Love, Brad
Freund, John
Caffrey, James J
Young, M Brook
Sendera, Timothy J
Magnuson, Scott R
Braughler, J Mark
Combined histomorphometric and gene-expression profiling applied to toxicology
title Combined histomorphometric and gene-expression profiling applied to toxicology
title_full Combined histomorphometric and gene-expression profiling applied to toxicology
title_fullStr Combined histomorphometric and gene-expression profiling applied to toxicology
title_full_unstemmed Combined histomorphometric and gene-expression profiling applied to toxicology
title_short Combined histomorphometric and gene-expression profiling applied to toxicology
title_sort combined histomorphometric and gene-expression profiling applied to toxicology
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156588/
https://www.ncbi.nlm.nih.gov/pubmed/12734012
http://dx.doi.org/10.1186/gb-2003-4-5-r32
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