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Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.

The principal epidemiologic evidence that environmental tobacco smoke (ETS) increases the risk of lung cancer in (lifelong) nonsmokers is from studies of nonsmoking women married to smokers. This article estimates exposure-response curves for 14 studies (1, 249+ cases, 7 countries) with data on lung...

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Autor principal: Brown, K G
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566198/
https://www.ncbi.nlm.nih.gov/pubmed/10592148
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author Brown, K G
author_facet Brown, K G
author_sort Brown, K G
collection PubMed
description The principal epidemiologic evidence that environmental tobacco smoke (ETS) increases the risk of lung cancer in (lifelong) nonsmokers is from studies of nonsmoking women married to smokers. This article estimates exposure-response curves for 14 studies (1, 249+ cases, 7 countries) with data on lung cancer categorized by the number of cigarettes/day smoked by the husband. The pooled results from the five U.S. studies alone are extrapolated to ETS levels in the workplace using measures of serum cotinine and nicotine samples from personal monitors as markers of exposure to ETS. It is predicted that the increase in lung cancer risk for nonsmoking women from average ETS exposure at work (among those exposed at work) is on the order of 25% (95% confidence interval (CI) = 8, 41) relative to background risk (i.e., with no ETS exposure from any source). This compares to an estimate of 39% (95% CI = 5, 65) for nonsmoking women whose husbands smoke at the adult male smoker's average of 25 cigarettes/day. At the 95th percentiles of exposure, the estimate from spousal smoking is 85% (95% CI = 32, 156), compared to 91% (95% CI = 34, 167) from workplace ETS exposure. Subject to the validity of the assumptions required in this approach, the outcome supports the conclusion that there is a significant excess risk from occupational exposure to ETS. The excess risk from ETS at work is typically lower than that from spousal smoking, but may be higher at the 95th percentiles of exposure.
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spelling pubmed-15661982006-09-19 Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers. Brown, K G Environ Health Perspect Research Article The principal epidemiologic evidence that environmental tobacco smoke (ETS) increases the risk of lung cancer in (lifelong) nonsmokers is from studies of nonsmoking women married to smokers. This article estimates exposure-response curves for 14 studies (1, 249+ cases, 7 countries) with data on lung cancer categorized by the number of cigarettes/day smoked by the husband. The pooled results from the five U.S. studies alone are extrapolated to ETS levels in the workplace using measures of serum cotinine and nicotine samples from personal monitors as markers of exposure to ETS. It is predicted that the increase in lung cancer risk for nonsmoking women from average ETS exposure at work (among those exposed at work) is on the order of 25% (95% confidence interval (CI) = 8, 41) relative to background risk (i.e., with no ETS exposure from any source). This compares to an estimate of 39% (95% CI = 5, 65) for nonsmoking women whose husbands smoke at the adult male smoker's average of 25 cigarettes/day. At the 95th percentiles of exposure, the estimate from spousal smoking is 85% (95% CI = 32, 156), compared to 91% (95% CI = 34, 167) from workplace ETS exposure. Subject to the validity of the assumptions required in this approach, the outcome supports the conclusion that there is a significant excess risk from occupational exposure to ETS. The excess risk from ETS at work is typically lower than that from spousal smoking, but may be higher at the 95th percentiles of exposure. 1999-12 /pmc/articles/PMC1566198/ /pubmed/10592148 Text en
spellingShingle Research Article
Brown, K G
Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title_full Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title_fullStr Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title_full_unstemmed Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title_short Lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
title_sort lung cancer and environmental tobacco smoke: occupational risk to nonsmokers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566198/
https://www.ncbi.nlm.nih.gov/pubmed/10592148
work_keys_str_mv AT brownkg lungcancerandenvironmentaltobaccosmokeoccupationalrisktononsmokers