The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting beta cells found in the islets of Langerhans. Reduced beta-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of num...

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Detalles Bibliográficos
Autores principales: Kraine, M R, Tisch, R M
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566241/
https://www.ncbi.nlm.nih.gov/pubmed/10502544
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author Kraine, M R
Tisch, R M
author_facet Kraine, M R
Tisch, R M
author_sort Kraine, M R
collection PubMed
description Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting beta cells found in the islets of Langerhans. Reduced beta-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of numerous sequelae. Incidence and development of IDDM depend upon a variety of genetic and nongenetic factors. Environmental factors such as chemicals, diet, and infection are suspected to influence the development of disease. This review describes the work performed to date to elucidate the role of these environmental factors in IDDM.
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spelling pubmed-15662412006-09-19 The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue. Kraine, M R Tisch, R M Environ Health Perspect Research Article Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting beta cells found in the islets of Langerhans. Reduced beta-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of numerous sequelae. Incidence and development of IDDM depend upon a variety of genetic and nongenetic factors. Environmental factors such as chemicals, diet, and infection are suspected to influence the development of disease. This review describes the work performed to date to elucidate the role of these environmental factors in IDDM. 1999-10 /pmc/articles/PMC1566241/ /pubmed/10502544 Text en
spellingShingle Research Article
Kraine, M R
Tisch, R M
The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title_full The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title_fullStr The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title_full_unstemmed The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title_short The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
title_sort role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566241/
https://www.ncbi.nlm.nih.gov/pubmed/10502544
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