Relationship between allergic contact dermatitis and electrophilicity.

To evaluate the role of electrophilicity in the induction of allergic contact dermatitis (ACD) in humans, we compared the structure-activity relationship (SAR) model of ACD with those of electrophilic and nonelectrophilic subsets of chemicals in the ACD database. For these analyses, electrophilicity...

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Detalles Bibliográficos
Autores principales: Rosenkranz, H S, Klopman, G, Zhang, Y P, Graham, C, Karol, M H
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566336/
https://www.ncbi.nlm.nih.gov/pubmed/9924008
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author Rosenkranz, H S
Klopman, G
Zhang, Y P
Graham, C
Karol, M H
author_facet Rosenkranz, H S
Klopman, G
Zhang, Y P
Graham, C
Karol, M H
author_sort Rosenkranz, H S
collection PubMed
description To evaluate the role of electrophilicity in the induction of allergic contact dermatitis (ACD) in humans, we compared the structure-activity relationship (SAR) model of ACD with those of electrophilic and nonelectrophilic subsets of chemicals in the ACD database. For these analyses, electrophilicity was defined as the potential of a chemical to induce mutations in Salmonella. It was found that electrophilicity accounted for approximately 30-40% of ACD-inducing ability, and the remainder was associated with nonelectrophilic structures. The identification of these moieties opens the possibility for studying their role in ACD.
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spelling pubmed-15663362006-09-19 Relationship between allergic contact dermatitis and electrophilicity. Rosenkranz, H S Klopman, G Zhang, Y P Graham, C Karol, M H Environ Health Perspect Research Article To evaluate the role of electrophilicity in the induction of allergic contact dermatitis (ACD) in humans, we compared the structure-activity relationship (SAR) model of ACD with those of electrophilic and nonelectrophilic subsets of chemicals in the ACD database. For these analyses, electrophilicity was defined as the potential of a chemical to induce mutations in Salmonella. It was found that electrophilicity accounted for approximately 30-40% of ACD-inducing ability, and the remainder was associated with nonelectrophilic structures. The identification of these moieties opens the possibility for studying their role in ACD. 1999-02 /pmc/articles/PMC1566336/ /pubmed/9924008 Text en
spellingShingle Research Article
Rosenkranz, H S
Klopman, G
Zhang, Y P
Graham, C
Karol, M H
Relationship between allergic contact dermatitis and electrophilicity.
title Relationship between allergic contact dermatitis and electrophilicity.
title_full Relationship between allergic contact dermatitis and electrophilicity.
title_fullStr Relationship between allergic contact dermatitis and electrophilicity.
title_full_unstemmed Relationship between allergic contact dermatitis and electrophilicity.
title_short Relationship between allergic contact dermatitis and electrophilicity.
title_sort relationship between allergic contact dermatitis and electrophilicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566336/
https://www.ncbi.nlm.nih.gov/pubmed/9924008
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AT zhangyp relationshipbetweenallergiccontactdermatitisandelectrophilicity
AT grahamc relationshipbetweenallergiccontactdermatitisandelectrophilicity
AT karolmh relationshipbetweenallergiccontactdermatitisandelectrophilicity

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