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Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.

Despite rising interest in the health problems of the elderly, information on senescence-related alterations in essential metabolic pathways and their responses to various chemicals is scarce. Although peroxisomal pathways are involved in a multitude of cellular functions, little attention has been...

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Detalles Bibliográficos
Autores principales: Youssef, J, Badr, M
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566613/
https://www.ncbi.nlm.nih.gov/pubmed/10504144
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author Youssef, J
Badr, M
author_facet Youssef, J
Badr, M
author_sort Youssef, J
collection PubMed
description Despite rising interest in the health problems of the elderly, information on senescence-related alterations in essential metabolic pathways and their responses to various chemicals is scarce. Although peroxisomal pathways are involved in a multitude of cellular functions, little attention has been given to the potential relationship between senescence of these organelles and the process of aging and disease. Although the prevailing experimental evidence points to a decline in liver peroxisomal enzyme activities and a muted response to peroxisome-proliferating chemicals in aged animals, it is also evident that aged animals are more susceptible, in comparison to their young counterparts, to the hepatocarcinogenic effects of these chemicals. Furthermore, little is known about extraperoxisomal effects of peroxisome proliferators in aged animals. This review evaluates published studies on the impact of aging on basal hepatic peroxisomal metabolism, response to peroxisome proliferators, and changes in signal transduction pathways involved in these processes, with the aim of stimulating research efforts in this important area. The potential intricate relationship among senescent peroxisomes, aged hepatocytes, and health are also discussed.
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spelling pubmed-15666132006-09-19 Biology of senescent liver peroxisomes: role in hepatocellular aging and disease. Youssef, J Badr, M Environ Health Perspect Research Article Despite rising interest in the health problems of the elderly, information on senescence-related alterations in essential metabolic pathways and their responses to various chemicals is scarce. Although peroxisomal pathways are involved in a multitude of cellular functions, little attention has been given to the potential relationship between senescence of these organelles and the process of aging and disease. Although the prevailing experimental evidence points to a decline in liver peroxisomal enzyme activities and a muted response to peroxisome-proliferating chemicals in aged animals, it is also evident that aged animals are more susceptible, in comparison to their young counterparts, to the hepatocarcinogenic effects of these chemicals. Furthermore, little is known about extraperoxisomal effects of peroxisome proliferators in aged animals. This review evaluates published studies on the impact of aging on basal hepatic peroxisomal metabolism, response to peroxisome proliferators, and changes in signal transduction pathways involved in these processes, with the aim of stimulating research efforts in this important area. The potential intricate relationship among senescent peroxisomes, aged hepatocytes, and health are also discussed. 1999-10 /pmc/articles/PMC1566613/ /pubmed/10504144 Text en
spellingShingle Research Article
Youssef, J
Badr, M
Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title_full Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title_fullStr Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title_full_unstemmed Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title_short Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
title_sort biology of senescent liver peroxisomes: role in hepatocellular aging and disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566613/
https://www.ncbi.nlm.nih.gov/pubmed/10504144
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