Effect of acetaminophen on glutathione levels in rat testis and lung.

Glutathione (GSH) levels in rat testis and lung after oral administration (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APAP value of 114 micrograms/g was obtained in testis at 6 hr (peak time); in the lung the Cm...

Descripción completa

Detalles Bibliográficos
Autores principales: Micheli, L, Cerretani, D, Fiaschi, A I, Giorgi, G, Romeo, M R, Runci, F M
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566779/
https://www.ncbi.nlm.nih.gov/pubmed/7698087
_version_ 1782129690930053120
author Micheli, L
Cerretani, D
Fiaschi, A I
Giorgi, G
Romeo, M R
Runci, F M
author_facet Micheli, L
Cerretani, D
Fiaschi, A I
Giorgi, G
Romeo, M R
Runci, F M
author_sort Micheli, L
collection PubMed
description Glutathione (GSH) levels in rat testis and lung after oral administration (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APAP value of 114 micrograms/g was obtained in testis at 6 hr (peak time); in the lung the Cmax was 92 mu/g at 8 hr and this value lasted several hours longer than that in testis. GSH levels are also affected differently in the organs studied after APAP administration; the lungs seem to be the primary organ undergoing the depleting action of APAP. This process could not only cause toxicity, but also predispose those organs to the action of toxic compounds responsible for specific pathologies.
format Text
id pubmed-1566779
institution National Center for Biotechnology Information
language English
publishDate 1994
record_format MEDLINE/PubMed
spelling pubmed-15667792006-09-19 Effect of acetaminophen on glutathione levels in rat testis and lung. Micheli, L Cerretani, D Fiaschi, A I Giorgi, G Romeo, M R Runci, F M Environ Health Perspect Research Article Glutathione (GSH) levels in rat testis and lung after oral administration (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APAP value of 114 micrograms/g was obtained in testis at 6 hr (peak time); in the lung the Cmax was 92 mu/g at 8 hr and this value lasted several hours longer than that in testis. GSH levels are also affected differently in the organs studied after APAP administration; the lungs seem to be the primary organ undergoing the depleting action of APAP. This process could not only cause toxicity, but also predispose those organs to the action of toxic compounds responsible for specific pathologies. 1994-11 /pmc/articles/PMC1566779/ /pubmed/7698087 Text en
spellingShingle Research Article
Micheli, L
Cerretani, D
Fiaschi, A I
Giorgi, G
Romeo, M R
Runci, F M
Effect of acetaminophen on glutathione levels in rat testis and lung.
title Effect of acetaminophen on glutathione levels in rat testis and lung.
title_full Effect of acetaminophen on glutathione levels in rat testis and lung.
title_fullStr Effect of acetaminophen on glutathione levels in rat testis and lung.
title_full_unstemmed Effect of acetaminophen on glutathione levels in rat testis and lung.
title_short Effect of acetaminophen on glutathione levels in rat testis and lung.
title_sort effect of acetaminophen on glutathione levels in rat testis and lung.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566779/
https://www.ncbi.nlm.nih.gov/pubmed/7698087
work_keys_str_mv AT michelil effectofacetaminophenonglutathionelevelsinrattestisandlung
AT cerretanid effectofacetaminophenonglutathionelevelsinrattestisandlung
AT fiaschiai effectofacetaminophenonglutathionelevelsinrattestisandlung
AT giorgig effectofacetaminophenonglutathionelevelsinrattestisandlung
AT romeomr effectofacetaminophenonglutathionelevelsinrattestisandlung
AT runcifm effectofacetaminophenonglutathionelevelsinrattestisandlung

Ejemplares similares