Oxygen radicals and asbestos carcinogenesis.

Asbestos fibers have been shown to generate reactive oxygen species using a variety of in vitro assays. It is hypothesized that these highly reactive metabolites mediate the development of malignant mesothelioma induced by asbestos fibers. DNA is a potential target of oxidant attack. Adaptive respon...

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Detalles Bibliográficos
Autores principales: Moyer, V D, Cistulli, C A, Vaslet, C A, Kane, A B
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566990/
https://www.ncbi.nlm.nih.gov/pubmed/7705288
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author Moyer, V D
Cistulli, C A
Vaslet, C A
Kane, A B
author_facet Moyer, V D
Cistulli, C A
Vaslet, C A
Kane, A B
author_sort Moyer, V D
collection PubMed
description Asbestos fibers have been shown to generate reactive oxygen species using a variety of in vitro assays. It is hypothesized that these highly reactive metabolites mediate the development of malignant mesothelioma induced by asbestos fibers. DNA is a potential target of oxidant attack. Adaptive responses to oxidant injury have been described during exposure of mesothelial cells to asbestos fibers in vitro. Failure of these adaptive responses may lead to genetic instability and alterations in oncogenes and tumor suppressor genes that confer a proliferative advantage to emerging neoplastic mesothelial cells.
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spelling pubmed-15669902006-09-19 Oxygen radicals and asbestos carcinogenesis. Moyer, V D Cistulli, C A Vaslet, C A Kane, A B Environ Health Perspect Research Article Asbestos fibers have been shown to generate reactive oxygen species using a variety of in vitro assays. It is hypothesized that these highly reactive metabolites mediate the development of malignant mesothelioma induced by asbestos fibers. DNA is a potential target of oxidant attack. Adaptive responses to oxidant injury have been described during exposure of mesothelial cells to asbestos fibers in vitro. Failure of these adaptive responses may lead to genetic instability and alterations in oncogenes and tumor suppressor genes that confer a proliferative advantage to emerging neoplastic mesothelial cells. 1994-12 /pmc/articles/PMC1566990/ /pubmed/7705288 Text en
spellingShingle Research Article
Moyer, V D
Cistulli, C A
Vaslet, C A
Kane, A B
Oxygen radicals and asbestos carcinogenesis.
title Oxygen radicals and asbestos carcinogenesis.
title_full Oxygen radicals and asbestos carcinogenesis.
title_fullStr Oxygen radicals and asbestos carcinogenesis.
title_full_unstemmed Oxygen radicals and asbestos carcinogenesis.
title_short Oxygen radicals and asbestos carcinogenesis.
title_sort oxygen radicals and asbestos carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566990/
https://www.ncbi.nlm.nih.gov/pubmed/7705288
work_keys_str_mv AT moyervd oxygenradicalsandasbestoscarcinogenesis
AT cistullica oxygenradicalsandasbestoscarcinogenesis
AT vasletca oxygenradicalsandasbestoscarcinogenesis
AT kaneab oxygenradicalsandasbestoscarcinogenesis

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