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Biomarkers of carcinogen exposure and cancer risk in a coke plant.

To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic transformation (sputum epithelial cell membrane antigens binding by monoclonal antibodies against small cell lung...

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Detalles Bibliográficos
Autores principales: Assennato, G, Ferri, G M, Tockman, M S, Poirier, M C, Schoket, B, Porro, A, Corrado, V, Strickland, P T
Formato: Texto
Lenguaje:English
Publicado: 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567024/
https://www.ncbi.nlm.nih.gov/pubmed/8319632
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author Assennato, G
Ferri, G M
Tockman, M S
Poirier, M C
Schoket, B
Porro, A
Corrado, V
Strickland, P T
author_facet Assennato, G
Ferri, G M
Tockman, M S
Poirier, M C
Schoket, B
Porro, A
Corrado, V
Strickland, P T
author_sort Assennato, G
collection PubMed
description To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic transformation (sputum epithelial cell membrane antigens binding by monoclonal antibodies against small cell lung cancer and against nonsmall cell lung cancer), a survey of 350 coke-oven workers and 100 unexposed workers was planned. This paper reports a pilot investigation on a subgroup of 23 coke-oven workers and 8 unexposed controls. A "gas regulator" worker with positive tumor antigen binding was identified. Results show that smokers, subjects with decreased pulmonary function (forced expiratory volume in 1 sec/forced vital capacity% < 80), and those with morphological dysplasia of sputum cells have higher levels of DNA adducts. The gas regulators showed the highest values for adducts; however, no significant difference of adduct levels was found between the coke-oven group and unexposed controls.
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spelling pubmed-15670242006-09-18 Biomarkers of carcinogen exposure and cancer risk in a coke plant. Assennato, G Ferri, G M Tockman, M S Poirier, M C Schoket, B Porro, A Corrado, V Strickland, P T Environ Health Perspect Research Article To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic transformation (sputum epithelial cell membrane antigens binding by monoclonal antibodies against small cell lung cancer and against nonsmall cell lung cancer), a survey of 350 coke-oven workers and 100 unexposed workers was planned. This paper reports a pilot investigation on a subgroup of 23 coke-oven workers and 8 unexposed controls. A "gas regulator" worker with positive tumor antigen binding was identified. Results show that smokers, subjects with decreased pulmonary function (forced expiratory volume in 1 sec/forced vital capacity% < 80), and those with morphological dysplasia of sputum cells have higher levels of DNA adducts. The gas regulators showed the highest values for adducts; however, no significant difference of adduct levels was found between the coke-oven group and unexposed controls. 1993-03 /pmc/articles/PMC1567024/ /pubmed/8319632 Text en
spellingShingle Research Article
Assennato, G
Ferri, G M
Tockman, M S
Poirier, M C
Schoket, B
Porro, A
Corrado, V
Strickland, P T
Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title_full Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title_fullStr Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title_full_unstemmed Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title_short Biomarkers of carcinogen exposure and cancer risk in a coke plant.
title_sort biomarkers of carcinogen exposure and cancer risk in a coke plant.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567024/
https://www.ncbi.nlm.nih.gov/pubmed/8319632
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