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Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons.
Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wil...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567054/ https://www.ncbi.nlm.nih.gov/pubmed/8319640 |
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author | Rothman, N Poirier, M C Haas, R A Correa-Villasenor, A Ford, P Hansen, J A O'Toole, T Strickland, P T |
author_facet | Rothman, N Poirier, M C Haas, R A Correa-Villasenor, A Ford, P Hansen, J A O'Toole, T Strickland, P T |
author_sort | Rothman, N |
collection | PubMed |
description | Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) firefighters at two time points (early and late) during an active forest fire season. PAH-DNA adduct levels were not associated with recent firefighting activity, but were positively associated with frequency of charbroiled food consumption in the previous 2 weeks. In addition, adduct levels declined with time since last ingestion of charbroiled food. These studies indicate that recent consumption of charbroiled food contributes to the PAH-DNA adduct load in peripheral WBCs. |
format | Text |
id | pubmed-1567054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
record_format | MEDLINE/PubMed |
spelling | pubmed-15670542006-09-18 Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. Rothman, N Poirier, M C Haas, R A Correa-Villasenor, A Ford, P Hansen, J A O'Toole, T Strickland, P T Environ Health Perspect Research Article Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) firefighters at two time points (early and late) during an active forest fire season. PAH-DNA adduct levels were not associated with recent firefighting activity, but were positively associated with frequency of charbroiled food consumption in the previous 2 weeks. In addition, adduct levels declined with time since last ingestion of charbroiled food. These studies indicate that recent consumption of charbroiled food contributes to the PAH-DNA adduct load in peripheral WBCs. 1993-03 /pmc/articles/PMC1567054/ /pubmed/8319640 Text en |
spellingShingle | Research Article Rothman, N Poirier, M C Haas, R A Correa-Villasenor, A Ford, P Hansen, J A O'Toole, T Strickland, P T Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title | Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title_full | Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title_fullStr | Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title_full_unstemmed | Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title_short | Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
title_sort | association of pah-dna adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567054/ https://www.ncbi.nlm.nih.gov/pubmed/8319640 |
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