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Biopersistence of man-made vitreous silicate fibers in the human lung.

There is now a substantial body of experimental data on the pulmonary biopersistence of man-made vitreous silicate fibers (MMVSF), but human data are seriously lacking. Our knowledge in this field is essentially limited to a few reports of measurements of fibers retained in lung tissue samples taken...

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Autor principal: Sébastien, P
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567272/
https://www.ncbi.nlm.nih.gov/pubmed/7882938
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author Sébastien, P
author_facet Sébastien, P
author_sort Sébastien, P
collection PubMed
description There is now a substantial body of experimental data on the pulmonary biopersistence of man-made vitreous silicate fibers (MMVSF), but human data are seriously lacking. Our knowledge in this field is essentially limited to a few reports of measurements of fibers retained in lung tissue samples taken at autopsy from workers manufacturing these products. Three types of exposure were studied: fibrous glass, mineral wool, and refractory ceramic fibers. Overall, the available data do not provide evidence for substantial long-term retention of fibers in the human lung after occupational exposure to MMVSF dusts. A word of caution, however; the amount of data supporting the previous statement is much greater for fibrous glass than for either mineral wool or refractory ceramic fibers. There is no human data on the key question of the kinetics of pulmonary clearance of inhaled MMVSF.
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spelling pubmed-15672722006-09-19 Biopersistence of man-made vitreous silicate fibers in the human lung. Sébastien, P Environ Health Perspect Research Article There is now a substantial body of experimental data on the pulmonary biopersistence of man-made vitreous silicate fibers (MMVSF), but human data are seriously lacking. Our knowledge in this field is essentially limited to a few reports of measurements of fibers retained in lung tissue samples taken at autopsy from workers manufacturing these products. Three types of exposure were studied: fibrous glass, mineral wool, and refractory ceramic fibers. Overall, the available data do not provide evidence for substantial long-term retention of fibers in the human lung after occupational exposure to MMVSF dusts. A word of caution, however; the amount of data supporting the previous statement is much greater for fibrous glass than for either mineral wool or refractory ceramic fibers. There is no human data on the key question of the kinetics of pulmonary clearance of inhaled MMVSF. 1994-10 /pmc/articles/PMC1567272/ /pubmed/7882938 Text en
spellingShingle Research Article
Sébastien, P
Biopersistence of man-made vitreous silicate fibers in the human lung.
title Biopersistence of man-made vitreous silicate fibers in the human lung.
title_full Biopersistence of man-made vitreous silicate fibers in the human lung.
title_fullStr Biopersistence of man-made vitreous silicate fibers in the human lung.
title_full_unstemmed Biopersistence of man-made vitreous silicate fibers in the human lung.
title_short Biopersistence of man-made vitreous silicate fibers in the human lung.
title_sort biopersistence of man-made vitreous silicate fibers in the human lung.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567272/
https://www.ncbi.nlm.nih.gov/pubmed/7882938
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