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Material-tissue interfaces: the role of surface properties and processes.

The introduction of a foreign material into living tissue--intentionally as in biomedical applications (implants, protheses, drugs) or unintentionally as when minerals or fibers are inhaled--results in the creation of interfaces between the material and the surrounding tissue. This article identifie...

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Detalles Bibliográficos
Autores principales: Kasemo, B, Lausmaa, J
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567278/
https://www.ncbi.nlm.nih.gov/pubmed/7882954
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author Kasemo, B
Lausmaa, J
author_facet Kasemo, B
Lausmaa, J
author_sort Kasemo, B
collection PubMed
description The introduction of a foreign material into living tissue--intentionally as in biomedical applications (implants, protheses, drugs) or unintentionally as when minerals or fibers are inhaled--results in the creation of interfaces between the material and the surrounding tissue. This article identifies and discusses the possible role of material surface properties and molecular processes occurring at such interfaces. For kinetic and thermodynamic reasons, surfaces are different from the corresponding bulk of the material, and contain reactive (unsaturated) bonds, which in turn lead to the formation of surface reactive layers (e.g., surface oxides on metals) and adsorbed contamination layers. The encounter with the biological environment leads to further surface reactions modifying the surface, and to the adsorption of water, ions, and biomolecules, which are continuously exchanged. The exact nature of the dynamic, adsorbed water, ions, and biomolecule coating in turn influences the behavior of cells approaching the material surface, and hence the tissue response.
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spelling pubmed-15672782006-09-19 Material-tissue interfaces: the role of surface properties and processes. Kasemo, B Lausmaa, J Environ Health Perspect Research Article The introduction of a foreign material into living tissue--intentionally as in biomedical applications (implants, protheses, drugs) or unintentionally as when minerals or fibers are inhaled--results in the creation of interfaces between the material and the surrounding tissue. This article identifies and discusses the possible role of material surface properties and molecular processes occurring at such interfaces. For kinetic and thermodynamic reasons, surfaces are different from the corresponding bulk of the material, and contain reactive (unsaturated) bonds, which in turn lead to the formation of surface reactive layers (e.g., surface oxides on metals) and adsorbed contamination layers. The encounter with the biological environment leads to further surface reactions modifying the surface, and to the adsorption of water, ions, and biomolecules, which are continuously exchanged. The exact nature of the dynamic, adsorbed water, ions, and biomolecule coating in turn influences the behavior of cells approaching the material surface, and hence the tissue response. 1994-10 /pmc/articles/PMC1567278/ /pubmed/7882954 Text en
spellingShingle Research Article
Kasemo, B
Lausmaa, J
Material-tissue interfaces: the role of surface properties and processes.
title Material-tissue interfaces: the role of surface properties and processes.
title_full Material-tissue interfaces: the role of surface properties and processes.
title_fullStr Material-tissue interfaces: the role of surface properties and processes.
title_full_unstemmed Material-tissue interfaces: the role of surface properties and processes.
title_short Material-tissue interfaces: the role of surface properties and processes.
title_sort material-tissue interfaces: the role of surface properties and processes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567278/
https://www.ncbi.nlm.nih.gov/pubmed/7882954
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AT lausmaaj materialtissueinterfacestheroleofsurfacepropertiesandprocesses