Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.

The aim of this study was to evaluate the efficiency of oral treatment with sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) on reducing mercury deposits in rat kidney after chronic exposure to inorganic mercury. The effect on kidney copper levels was also evaluated. The results showed that after two...

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Detalles Bibliográficos
Autores principales: Blanusa, M, Prester, L, Radić, S, Kargacin, B
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567378/
https://www.ncbi.nlm.nih.gov/pubmed/7843122
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author Blanusa, M
Prester, L
Radić, S
Kargacin, B
author_facet Blanusa, M
Prester, L
Radić, S
Kargacin, B
author_sort Blanusa, M
collection PubMed
description The aim of this study was to evaluate the efficiency of oral treatment with sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) on reducing mercury deposits in rat kidney after chronic exposure to inorganic mercury. The effect on kidney copper levels was also evaluated. The results showed that after two months of exposure to 50 ppm of mercury (as mercuric chloride) the concentration of mercury in the kidney was 124 micrograms/g wet tissue. At the same time copper concentration rose from 11 to 77 micrograms/g. DMPS treatment caused 2- and almost 4-fold reduction of mercury and copper, respectively. This study demonstrates that chronic exposure to inorganic mercury may alter metabolism of copper and that DMPS is an effective means for reduction of both mercury and copper.
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spelling pubmed-15673782006-09-19 Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats. Blanusa, M Prester, L Radić, S Kargacin, B Environ Health Perspect Research Article The aim of this study was to evaluate the efficiency of oral treatment with sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) on reducing mercury deposits in rat kidney after chronic exposure to inorganic mercury. The effect on kidney copper levels was also evaluated. The results showed that after two months of exposure to 50 ppm of mercury (as mercuric chloride) the concentration of mercury in the kidney was 124 micrograms/g wet tissue. At the same time copper concentration rose from 11 to 77 micrograms/g. DMPS treatment caused 2- and almost 4-fold reduction of mercury and copper, respectively. This study demonstrates that chronic exposure to inorganic mercury may alter metabolism of copper and that DMPS is an effective means for reduction of both mercury and copper. 1994-09 /pmc/articles/PMC1567378/ /pubmed/7843122 Text en
spellingShingle Research Article
Blanusa, M
Prester, L
Radić, S
Kargacin, B
Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title_full Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title_fullStr Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title_full_unstemmed Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title_short Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
title_sort inorganic mercury exposure, mercury-copper interaction, and dmps treatment in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567378/
https://www.ncbi.nlm.nih.gov/pubmed/7843122
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AT presterl inorganicmercuryexposuremercurycopperinteractionanddmpstreatmentinrats
AT radics inorganicmercuryexposuremercurycopperinteractionanddmpstreatmentinrats
AT kargacinb inorganicmercuryexposuremercurycopperinteractionanddmpstreatmentinrats

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