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Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.

Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biologica...

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Detalles Bibliográficos
Autor principal: Sugiyama, M
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567401/
https://www.ncbi.nlm.nih.gov/pubmed/7843124
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author Sugiyama, M
author_facet Sugiyama, M
author_sort Sugiyama, M
collection PubMed
description Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biological effects of chromium(VI) compounds. The present report, uses electron spin resonance (ESR) spectroscopy; the importance of the role of paramagnetic chromium in chromium(VI)-induced damage in intact cultured cells is discussed, based upon our studies with antioxidants including vitamin E (alpha-tocopherol), B2 (riboflavin), C (ascorbic acid), and so on. These studies appear to confirm the participation of paramagnetic Cr such as chromium(V) and Chromium(III) in chromium(VI)-induced cellular damage.
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spelling pubmed-15674012006-09-19 Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells. Sugiyama, M Environ Health Perspect Research Article Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biological effects of chromium(VI) compounds. The present report, uses electron spin resonance (ESR) spectroscopy; the importance of the role of paramagnetic chromium in chromium(VI)-induced damage in intact cultured cells is discussed, based upon our studies with antioxidants including vitamin E (alpha-tocopherol), B2 (riboflavin), C (ascorbic acid), and so on. These studies appear to confirm the participation of paramagnetic Cr such as chromium(V) and Chromium(III) in chromium(VI)-induced cellular damage. 1994-09 /pmc/articles/PMC1567401/ /pubmed/7843124 Text en
spellingShingle Research Article
Sugiyama, M
Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title_full Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title_fullStr Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title_full_unstemmed Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title_short Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
title_sort role of paramagnetic chromium in chromium(vi)-induced damage in cultured mammalian cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567401/
https://www.ncbi.nlm.nih.gov/pubmed/7843124
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