Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.

Isolated nuclei from mammalian cells contain a calcium-dependent endonuclease. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis (programmed cell death). We report here that zinc and cadmium inhibit the calcium-dependent endonuclease. The essential m...

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Detalles Bibliográficos
Autores principales: Lohmann, R D, Beyersmann, D
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567406/
https://www.ncbi.nlm.nih.gov/pubmed/7843111
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author Lohmann, R D
Beyersmann, D
author_facet Lohmann, R D
Beyersmann, D
author_sort Lohmann, R D
collection PubMed
description Isolated nuclei from mammalian cells contain a calcium-dependent endonuclease. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis (programmed cell death). We report here that zinc and cadmium inhibit the calcium-dependent endonuclease. The essential metal ion zinc may counterbalance the calcium-mediated apoptosis. In contrast to zinc, cadmium alone stimulates the endonuclease by replacing calcium. Thus cadmium exerts a dual effect: micromolar concentrations inhibit the apoptotic endonuclease in the presence but activate the enzyme in the absence of calcium.
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spelling pubmed-15674062006-09-19 Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei. Lohmann, R D Beyersmann, D Environ Health Perspect Research Article Isolated nuclei from mammalian cells contain a calcium-dependent endonuclease. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis (programmed cell death). We report here that zinc and cadmium inhibit the calcium-dependent endonuclease. The essential metal ion zinc may counterbalance the calcium-mediated apoptosis. In contrast to zinc, cadmium alone stimulates the endonuclease by replacing calcium. Thus cadmium exerts a dual effect: micromolar concentrations inhibit the apoptotic endonuclease in the presence but activate the enzyme in the absence of calcium. 1994-09 /pmc/articles/PMC1567406/ /pubmed/7843111 Text en
spellingShingle Research Article
Lohmann, R D
Beyersmann, D
Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title_full Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title_fullStr Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title_full_unstemmed Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title_short Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.
title_sort effects of zinc and cadmium on apoptotic dna fragmentation in isolated bovine liver nuclei.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567406/
https://www.ncbi.nlm.nih.gov/pubmed/7843111
work_keys_str_mv AT lohmannrd effectsofzincandcadmiumonapoptoticdnafragmentationinisolatedbovinelivernuclei
AT beyersmannd effectsofzincandcadmiumonapoptoticdnafragmentationinisolatedbovinelivernuclei

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