Active oxygen species in DNA damage induced by carcinogenic metal compounds.

Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage; 8-hydroxyl-2...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawanishi, S, Inoue, S, Yamamoto, K
Formato: Texto
Lenguaje:English
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567415/
https://www.ncbi.nlm.nih.gov/pubmed/7843093
_version_ 1782129823550799872
author Kawanishi, S
Inoue, S
Yamamoto, K
author_facet Kawanishi, S
Inoue, S
Yamamoto, K
author_sort Kawanishi, S
collection PubMed
description Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage; 8-hydroxyl-2'-deoxyguanosine formation is included in the DNA damage. Using pulsed-field gel electrophoresis, nickel sulfide was shown to induce oxidative DNA cleavage in cultured cells. On the basis of these findings, we have emphasized the role of oxygen radicals in metal carcinogenesis.
format Text
id pubmed-1567415
institution National Center for Biotechnology Information
language English
publishDate 1994
record_format MEDLINE/PubMed
spelling pubmed-15674152006-09-19 Active oxygen species in DNA damage induced by carcinogenic metal compounds. Kawanishi, S Inoue, S Yamamoto, K Environ Health Perspect Research Article Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage; 8-hydroxyl-2'-deoxyguanosine formation is included in the DNA damage. Using pulsed-field gel electrophoresis, nickel sulfide was shown to induce oxidative DNA cleavage in cultured cells. On the basis of these findings, we have emphasized the role of oxygen radicals in metal carcinogenesis. 1994-09 /pmc/articles/PMC1567415/ /pubmed/7843093 Text en
spellingShingle Research Article
Kawanishi, S
Inoue, S
Yamamoto, K
Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title_full Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title_fullStr Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title_full_unstemmed Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title_short Active oxygen species in DNA damage induced by carcinogenic metal compounds.
title_sort active oxygen species in dna damage induced by carcinogenic metal compounds.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567415/
https://www.ncbi.nlm.nih.gov/pubmed/7843093
work_keys_str_mv AT kawanishis activeoxygenspeciesindnadamageinducedbycarcinogenicmetalcompounds
AT inoues activeoxygenspeciesindnadamageinducedbycarcinogenicmetalcompounds
AT yamamotok activeoxygenspeciesindnadamageinducedbycarcinogenicmetalcompounds

Ejemplares similares