Cargando…
Quantitative mechanistically based dose-response modeling with endocrine-active compounds.
A wide range of toxicity test methods is used or is being developed for assessing the impact of endocrine-active compounds (EACs) on human health. Interpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically bas...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
1999
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567506/ https://www.ncbi.nlm.nih.gov/pubmed/10421774 |
_version_ | 1782129841949114368 |
---|---|
author | Andersen, M E Conolly, R B Faustman, E M Kavlock, R J Portier, C J Sheehan, D M Wier, P J Ziese, L |
author_facet | Andersen, M E Conolly, R B Faustman, E M Kavlock, R J Portier, C J Sheehan, D M Wier, P J Ziese, L |
author_sort | Andersen, M E |
collection | PubMed |
description | A wide range of toxicity test methods is used or is being developed for assessing the impact of endocrine-active compounds (EACs) on human health. Interpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically based dose-response (MBDR) models to assist low-dose, interspecies, and (italic)in vitro(/italic) to (italic)in vivo(/italic) extrapolations. A quantitative dose-response modeling work group examined the state of the art for developing MBDR models for EACs and the near-term needs to develop, validate, and apply these models for risk assessments. Major aspects of this report relate to current status of these models, the objectives/goals in MBDR model development for EACs, low-dose extrapolation issues, regulatory inertia impeding acceptance of these approaches, and resource/data needs to accelerate model development and model acceptance by the research and the regulatory community. |
format | Text |
id | pubmed-1567506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
record_format | MEDLINE/PubMed |
spelling | pubmed-15675062006-09-19 Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Andersen, M E Conolly, R B Faustman, E M Kavlock, R J Portier, C J Sheehan, D M Wier, P J Ziese, L Environ Health Perspect Research Article A wide range of toxicity test methods is used or is being developed for assessing the impact of endocrine-active compounds (EACs) on human health. Interpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically based dose-response (MBDR) models to assist low-dose, interspecies, and (italic)in vitro(/italic) to (italic)in vivo(/italic) extrapolations. A quantitative dose-response modeling work group examined the state of the art for developing MBDR models for EACs and the near-term needs to develop, validate, and apply these models for risk assessments. Major aspects of this report relate to current status of these models, the objectives/goals in MBDR model development for EACs, low-dose extrapolation issues, regulatory inertia impeding acceptance of these approaches, and resource/data needs to accelerate model development and model acceptance by the research and the regulatory community. 1999-08 /pmc/articles/PMC1567506/ /pubmed/10421774 Text en |
spellingShingle | Research Article Andersen, M E Conolly, R B Faustman, E M Kavlock, R J Portier, C J Sheehan, D M Wier, P J Ziese, L Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title_full | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title_fullStr | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title_full_unstemmed | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title_short | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
title_sort | quantitative mechanistically based dose-response modeling with endocrine-active compounds. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567506/ https://www.ncbi.nlm.nih.gov/pubmed/10421774 |
work_keys_str_mv | AT andersenme quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT conollyrb quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT faustmanem quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT kavlockrj quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT portiercj quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT sheehandm quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT wierpj quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds AT ziesel quantitativemechanisticallybaseddoseresponsemodelingwithendocrineactivecompounds |