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Response modification in carcinogenesis.

A major goal in multistep carcinogenesis research is the integration of recent findings obtained by sophisticated molecular-genetic and cytogenetic analysis of cancer into the more descriptive concepts of experimental pathology. It is proposed that the creation of a promotable cell in carcinogenic i...

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Detalles Bibliográficos
Autor principal: Cerutti, P A
Formato: Texto
Lenguaje:English
Publicado: 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567556/
https://www.ncbi.nlm.nih.gov/pubmed/2667983
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author Cerutti, P A
author_facet Cerutti, P A
author_sort Cerutti, P A
collection PubMed
description A major goal in multistep carcinogenesis research is the integration of recent findings obtained by sophisticated molecular-genetic and cytogenetic analysis of cancer into the more descriptive concepts of experimental pathology. It is proposed that the creation of a promotable cell in carcinogenic initiation requires a response modification to extracellular or intercellular signals. Different types of response modification can be distinguished: changes in the receptors for growth and differentiation factors and their cytoplasmic and nuclear signal transduction pathways; increased resistance of initiated cells to cytotoxic agents; alterations in junctional cell-to-cell communications. The challenge of a response-modified cell to an appropriate promoter results in its selection and clonal expansion, usually to a benign tumor. In addition, for malignancy, chromosomal changes are required that affect cellular functions that can play a role early or late in tumorigenesis. These concepts are illustrated with examples from oncogene research and oxidant promotion.
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spelling pubmed-15675562006-09-18 Response modification in carcinogenesis. Cerutti, P A Environ Health Perspect Research Article A major goal in multistep carcinogenesis research is the integration of recent findings obtained by sophisticated molecular-genetic and cytogenetic analysis of cancer into the more descriptive concepts of experimental pathology. It is proposed that the creation of a promotable cell in carcinogenic initiation requires a response modification to extracellular or intercellular signals. Different types of response modification can be distinguished: changes in the receptors for growth and differentiation factors and their cytoplasmic and nuclear signal transduction pathways; increased resistance of initiated cells to cytotoxic agents; alterations in junctional cell-to-cell communications. The challenge of a response-modified cell to an appropriate promoter results in its selection and clonal expansion, usually to a benign tumor. In addition, for malignancy, chromosomal changes are required that affect cellular functions that can play a role early or late in tumorigenesis. These concepts are illustrated with examples from oncogene research and oxidant promotion. 1989-05 /pmc/articles/PMC1567556/ /pubmed/2667983 Text en
spellingShingle Research Article
Cerutti, P A
Response modification in carcinogenesis.
title Response modification in carcinogenesis.
title_full Response modification in carcinogenesis.
title_fullStr Response modification in carcinogenesis.
title_full_unstemmed Response modification in carcinogenesis.
title_short Response modification in carcinogenesis.
title_sort response modification in carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567556/
https://www.ncbi.nlm.nih.gov/pubmed/2667983
work_keys_str_mv AT ceruttipa responsemodificationincarcinogenesis