Coupling growth arrest and adipocyte differentiation.

The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early...

Descripción completa

Detalles Bibliográficos
Autores principales: Ailhaud, G, Dani, C, Amri, E Z, Djian, P, Vannier, C, Doglio, A, Forest, C, Gaillard, D, Négrel, R, Grimaldi, P
Formato: Texto
Lenguaje:English
Publicado: 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567619/
https://www.ncbi.nlm.nih.gov/pubmed/2647477
Descripción
Sumario:The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early marker-containing cells. Only terminal differentiation requires the presence of growth hormone and triiodothyronine and results in the formation of triacylglycerol-filled, nondividing cells. The events of adipose cell differentiation which take place in vitro allow a better understanding of the development of adipose tissue in vivo.