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Toward the twenty-first century: lessons from lead and lessons yet to learn.

A consideration of recent research on lead is instructive for developing research strategies in environmental toxicology. Lead research has demonstrated fruitful interactions between clinical and basic science. Thus, while epidemiological studies have suggested that central nervous system (CNS) effe...

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Detalles Bibliográficos
Autor principal: Silbergeld, E K
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567732/
https://www.ncbi.nlm.nih.gov/pubmed/2205489
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author Silbergeld, E K
author_facet Silbergeld, E K
author_sort Silbergeld, E K
collection PubMed
description A consideration of recent research on lead is instructive for developing research strategies in environmental toxicology. Lead research has demonstrated fruitful interactions between clinical and basic science. Thus, while epidemiological studies have suggested that central nervous system (CNS) effects in children are observed at the lowest increments of lead exposure, basic research has elucidated some of the molecular events that underly this lack of threshold at the neuronal level. Similarly, clinical studies indicate that early exposure to lead produces functionally irreversible damage to the CNS; experimental research demonstrates that this irreversibility may involve failure to remove lead from brain, permanent effects on synaptogenesis; and chelant-induced redistribution of lead from the periphery to the CNS. Lead toxicokinetics demand reevaluation. New data on release of bone stores of lead during physiological conditions of demineralization indicate that mobilization of bone lead adds to in utero exposure of the fetus. Furthermore, postmenopausal demineralization of bone can increase blood lead levels in women by 25%; this raises concern about the potential effects of lead in an aging population and the difficulties in comprehensive exposure assessment.
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spelling pubmed-15677322006-09-18 Toward the twenty-first century: lessons from lead and lessons yet to learn. Silbergeld, E K Environ Health Perspect Research Article A consideration of recent research on lead is instructive for developing research strategies in environmental toxicology. Lead research has demonstrated fruitful interactions between clinical and basic science. Thus, while epidemiological studies have suggested that central nervous system (CNS) effects in children are observed at the lowest increments of lead exposure, basic research has elucidated some of the molecular events that underly this lack of threshold at the neuronal level. Similarly, clinical studies indicate that early exposure to lead produces functionally irreversible damage to the CNS; experimental research demonstrates that this irreversibility may involve failure to remove lead from brain, permanent effects on synaptogenesis; and chelant-induced redistribution of lead from the periphery to the CNS. Lead toxicokinetics demand reevaluation. New data on release of bone stores of lead during physiological conditions of demineralization indicate that mobilization of bone lead adds to in utero exposure of the fetus. Furthermore, postmenopausal demineralization of bone can increase blood lead levels in women by 25%; this raises concern about the potential effects of lead in an aging population and the difficulties in comprehensive exposure assessment. 1990-06 /pmc/articles/PMC1567732/ /pubmed/2205489 Text en
spellingShingle Research Article
Silbergeld, E K
Toward the twenty-first century: lessons from lead and lessons yet to learn.
title Toward the twenty-first century: lessons from lead and lessons yet to learn.
title_full Toward the twenty-first century: lessons from lead and lessons yet to learn.
title_fullStr Toward the twenty-first century: lessons from lead and lessons yet to learn.
title_full_unstemmed Toward the twenty-first century: lessons from lead and lessons yet to learn.
title_short Toward the twenty-first century: lessons from lead and lessons yet to learn.
title_sort toward the twenty-first century: lessons from lead and lessons yet to learn.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567732/
https://www.ncbi.nlm.nih.gov/pubmed/2205489
work_keys_str_mv AT silbergeldek towardthetwentyfirstcenturylessonsfromleadandlessonsyettolearn