An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.

Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multid...

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Detalles Bibliográficos
Autores principales: Chhabra, R S, Huff, J E, Schwetz, B S, Selkirk, J
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567743/
https://www.ncbi.nlm.nih.gov/pubmed/2205492
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author Chhabra, R S
Huff, J E
Schwetz, B S
Selkirk, J
author_facet Chhabra, R S
Huff, J E
Schwetz, B S
Selkirk, J
author_sort Chhabra, R S
collection PubMed
description Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multidisciplinary approach to evaluating chemicals. This paper describes the scientific rationale and experimental processes used by NTP in designing studies. Also, an outline of current NTP protocols are given for prechronic and chronic toxicity/carcinogenicity studies.
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spelling pubmed-15677432006-09-18 An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Chhabra, R S Huff, J E Schwetz, B S Selkirk, J Environ Health Perspect Research Article Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multidisciplinary approach to evaluating chemicals. This paper describes the scientific rationale and experimental processes used by NTP in designing studies. Also, an outline of current NTP protocols are given for prechronic and chronic toxicity/carcinogenicity studies. 1990-06 /pmc/articles/PMC1567743/ /pubmed/2205492 Text en
spellingShingle Research Article
Chhabra, R S
Huff, J E
Schwetz, B S
Selkirk, J
An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title_full An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title_fullStr An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title_full_unstemmed An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title_short An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
title_sort overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the national toxicology program.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567743/
https://www.ncbi.nlm.nih.gov/pubmed/2205492
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