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Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.

The mechanisms and sites of action of organochlorine (DDT-types and chlorinated alicyclics) and synthetic pyrethroid insecticides are presented with discussion of symptoms, physiological effects, and selectivity. The structural requirements for toxicity are assessed, and structure-activity relations...

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Detalles Bibliográficos
Autor principal: Coats, J R
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567810/
https://www.ncbi.nlm.nih.gov/pubmed/2176589
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author Coats, J R
author_facet Coats, J R
author_sort Coats, J R
collection PubMed
description The mechanisms and sites of action of organochlorine (DDT-types and chlorinated alicyclics) and synthetic pyrethroid insecticides are presented with discussion of symptoms, physiological effects, and selectivity. The structural requirements for toxicity are assessed, and structure-activity relationships are considered for each subclass. Lipophilicity is important for all the groups because it facilitates delivery of these neurotoxicants to the site of action in the nerve. Steric factors including molecular volume, shape, and isomeric configuration greatly influence toxicity. Electronic parameters also have been demonstrated to affect biological activity in some of the groups of insecticides, e.g., Hammett's sigma and Taft's sigma * as indicators of electronegativity. New synthetic pyrethroids continue to be developed, with varied structures and different physicochemical and biological properties.
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spelling pubmed-15678102006-09-18 Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides. Coats, J R Environ Health Perspect Research Article The mechanisms and sites of action of organochlorine (DDT-types and chlorinated alicyclics) and synthetic pyrethroid insecticides are presented with discussion of symptoms, physiological effects, and selectivity. The structural requirements for toxicity are assessed, and structure-activity relationships are considered for each subclass. Lipophilicity is important for all the groups because it facilitates delivery of these neurotoxicants to the site of action in the nerve. Steric factors including molecular volume, shape, and isomeric configuration greatly influence toxicity. Electronic parameters also have been demonstrated to affect biological activity in some of the groups of insecticides, e.g., Hammett's sigma and Taft's sigma * as indicators of electronegativity. New synthetic pyrethroids continue to be developed, with varied structures and different physicochemical and biological properties. 1990-07 /pmc/articles/PMC1567810/ /pubmed/2176589 Text en
spellingShingle Research Article
Coats, J R
Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title_full Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title_fullStr Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title_full_unstemmed Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title_short Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
title_sort mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567810/
https://www.ncbi.nlm.nih.gov/pubmed/2176589
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