Human somatic mutation assays as biomarkers of carcinogenesis.

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays...

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Detalles Bibliográficos
Autores principales: Compton, P J, Hooper, K, Smith, M T
Formato: Texto
Lenguaje:English
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567966/
https://www.ncbi.nlm.nih.gov/pubmed/1954924
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author Compton, P J
Hooper, K
Smith, M T
author_facet Compton, P J
Hooper, K
Smith, M T
author_sort Compton, P J
collection PubMed
description This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed.
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spelling pubmed-15679662006-09-18 Human somatic mutation assays as biomarkers of carcinogenesis. Compton, P J Hooper, K Smith, M T Environ Health Perspect Research Article This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed. 1991-08 /pmc/articles/PMC1567966/ /pubmed/1954924 Text en
spellingShingle Research Article
Compton, P J
Hooper, K
Smith, M T
Human somatic mutation assays as biomarkers of carcinogenesis.
title Human somatic mutation assays as biomarkers of carcinogenesis.
title_full Human somatic mutation assays as biomarkers of carcinogenesis.
title_fullStr Human somatic mutation assays as biomarkers of carcinogenesis.
title_full_unstemmed Human somatic mutation assays as biomarkers of carcinogenesis.
title_short Human somatic mutation assays as biomarkers of carcinogenesis.
title_sort human somatic mutation assays as biomarkers of carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567966/
https://www.ncbi.nlm.nih.gov/pubmed/1954924
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AT hooperk humansomaticmutationassaysasbiomarkersofcarcinogenesis
AT smithmt humansomaticmutationassaysasbiomarkersofcarcinogenesis

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