Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.

The inhibition of differentiation and persistence of proliferation in cell transformation is probably not only caused by the mutation of single genes. An additional mechanism of transcriptional control, not only of single genes but of gene programs, is possibly the alteration of the topoisomerases....

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Autores principales: Gieseler, F, Boege, F, Clark, M
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567985/
https://www.ncbi.nlm.nih.gov/pubmed/2176973
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author Gieseler, F
Boege, F
Clark, M
author_facet Gieseler, F
Boege, F
Clark, M
author_sort Gieseler, F
collection PubMed
description The inhibition of differentiation and persistence of proliferation in cell transformation is probably not only caused by the mutation of single genes. An additional mechanism of transcriptional control, not only of single genes but of gene programs, is possibly the alteration of the topoisomerases. These enzymes regulate the conformation of DNA by twisting and unwinding the double strands. As has been shown previously, only the genes located in relaxed DNA areas are transcribed and, therefore, the topoisomerases can be described as a gene regulation device. We present the hypothesis that topoisomerase II action is not only altered in, but also necessary for, HL-60 granulocytic cell differentiation. Thus, alteration of topoisomerases may well be a molecular mechanism of cellular differentiation.
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spelling pubmed-15679852006-09-18 Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation. Gieseler, F Boege, F Clark, M Environ Health Perspect Research Article The inhibition of differentiation and persistence of proliferation in cell transformation is probably not only caused by the mutation of single genes. An additional mechanism of transcriptional control, not only of single genes but of gene programs, is possibly the alteration of the topoisomerases. These enzymes regulate the conformation of DNA by twisting and unwinding the double strands. As has been shown previously, only the genes located in relaxed DNA areas are transcribed and, therefore, the topoisomerases can be described as a gene regulation device. We present the hypothesis that topoisomerase II action is not only altered in, but also necessary for, HL-60 granulocytic cell differentiation. Thus, alteration of topoisomerases may well be a molecular mechanism of cellular differentiation. 1990-08 /pmc/articles/PMC1567985/ /pubmed/2176973 Text en
spellingShingle Research Article
Gieseler, F
Boege, F
Clark, M
Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title_full Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title_fullStr Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title_full_unstemmed Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title_short Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.
title_sort alteration of topoisomerase ii action is a possible molecular mechanism of hl-60 cell differentiation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567985/
https://www.ncbi.nlm.nih.gov/pubmed/2176973
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AT boegef alterationoftopoisomeraseiiactionisapossiblemolecularmechanismofhl60celldifferentiation
AT clarkm alterationoftopoisomeraseiiactionisapossiblemolecularmechanismofhl60celldifferentiation

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