Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.

V79 cells, genetically engineered to express active cytochromes P450IIB1 and P450IA1, were used to study the cytotoxicity and mutagenicity of cyclophosphamide and ifosfamide. Cyclophosphamide, tested up to a concentration of 2 mM, was not cytotoxic in V79 nor in the P450IA1-expressing V79-derived ce...

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Detalles Bibliográficos
Autores principales: Doehmer, J, Seidel, A, Oesch, F, Glatt, H R
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568032/
https://www.ncbi.nlm.nih.gov/pubmed/2272335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568032/
https://www.ncbi.nlm.nih.gov/pubmed/2272335

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