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Proliferative lesions of the exocrine pancreas in male F344/N rats.

While the rat pancreas is susceptible to experimental cancer induction, the spontaneous incidence of pancreatic cancer in this species is reported to be very low. However, we observed unusually high incidences of focal acinar hyperplasia and acinar adenoma in vehicle control male F344/N rats of some...

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Detalles Bibliográficos
Autores principales: Boorman, G A, Eustis, S L
Formato: Texto
Lenguaje:English
Publicado: 1984
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568212/
https://www.ncbi.nlm.nih.gov/pubmed/6434300
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author Boorman, G A
Eustis, S L
author_facet Boorman, G A
Eustis, S L
author_sort Boorman, G A
collection PubMed
description While the rat pancreas is susceptible to experimental cancer induction, the spontaneous incidence of pancreatic cancer in this species is reported to be very low. However, we observed unusually high incidences of focal acinar hyperplasia and acinar adenoma in vehicle control male F344/N rats of some NCI/NTP 2-year toxicological studies. The vehicle in these studies was corn oil given by gavage. Focal acinar hyperplasia, acinar adenoma, and acinar carcinoma (found rarely) represent a continuous spectrum of proliferative lesions of the exocrine pancreas. While the carcinomas have clear morphological indications of malignancy, the biological behavior of focal acinar hyperplasia and acinar adenoma is not known. Although induction of acinar carcinomas is considered clear evidence of carcinogenicity of a test chemical, significantly increased incidences in treated rats of acinar adenomas but not carcinomas provides some evidence of carcinogenicity. The association of acinar hyperplasia and adenoma with vegetable oil gavage complicates the interpretation when marginally elevated incidences of these lesions are observed in rats administered the test chemical in vegetable oil vehicle. Studies of the biological behavior of exocrine pancreatic lesions in male rats would be helpful in assessing the significance of their presence when found after test compound administration.
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spelling pubmed-15682122006-09-18 Proliferative lesions of the exocrine pancreas in male F344/N rats. Boorman, G A Eustis, S L Environ Health Perspect Research Article While the rat pancreas is susceptible to experimental cancer induction, the spontaneous incidence of pancreatic cancer in this species is reported to be very low. However, we observed unusually high incidences of focal acinar hyperplasia and acinar adenoma in vehicle control male F344/N rats of some NCI/NTP 2-year toxicological studies. The vehicle in these studies was corn oil given by gavage. Focal acinar hyperplasia, acinar adenoma, and acinar carcinoma (found rarely) represent a continuous spectrum of proliferative lesions of the exocrine pancreas. While the carcinomas have clear morphological indications of malignancy, the biological behavior of focal acinar hyperplasia and acinar adenoma is not known. Although induction of acinar carcinomas is considered clear evidence of carcinogenicity of a test chemical, significantly increased incidences in treated rats of acinar adenomas but not carcinomas provides some evidence of carcinogenicity. The association of acinar hyperplasia and adenoma with vegetable oil gavage complicates the interpretation when marginally elevated incidences of these lesions are observed in rats administered the test chemical in vegetable oil vehicle. Studies of the biological behavior of exocrine pancreatic lesions in male rats would be helpful in assessing the significance of their presence when found after test compound administration. 1984-06 /pmc/articles/PMC1568212/ /pubmed/6434300 Text en
spellingShingle Research Article
Boorman, G A
Eustis, S L
Proliferative lesions of the exocrine pancreas in male F344/N rats.
title Proliferative lesions of the exocrine pancreas in male F344/N rats.
title_full Proliferative lesions of the exocrine pancreas in male F344/N rats.
title_fullStr Proliferative lesions of the exocrine pancreas in male F344/N rats.
title_full_unstemmed Proliferative lesions of the exocrine pancreas in male F344/N rats.
title_short Proliferative lesions of the exocrine pancreas in male F344/N rats.
title_sort proliferative lesions of the exocrine pancreas in male f344/n rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568212/
https://www.ncbi.nlm.nih.gov/pubmed/6434300
work_keys_str_mv AT boormanga proliferativelesionsoftheexocrinepancreasinmalef344nrats
AT eustissl proliferativelesionsoftheexocrinepancreasinmalef344nrats