Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.

A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the muta...

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Detalles Bibliográficos
Autores principales: Bolsaitis, P P, Feitelberg, A S, Dekermendjian, V, Elliott, J F, Sarofim, A F, Thilly, W G
Formato: Texto
Lenguaje:English
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568249/
https://www.ncbi.nlm.nih.gov/pubmed/1820270
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author Bolsaitis, P P
Feitelberg, A S
Dekermendjian, V
Elliott, J F
Sarofim, A F
Thilly, W G
author_facet Bolsaitis, P P
Feitelberg, A S
Dekermendjian, V
Elliott, J F
Sarofim, A F
Thilly, W G
author_sort Bolsaitis, P P
collection PubMed
description A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH fraction is higher when it is contacted with cells as a liquid extract than when it is supplied as a coating on soot particles. The substrate particles were found to be nonmutagenic. The rate of transfer of mutagens from the surface of particles, combined with the retention time of respirable aerosol particles, are deemed to define their mutagenic potential.
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spelling pubmed-15682492006-09-18 Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles. Bolsaitis, P P Feitelberg, A S Dekermendjian, V Elliott, J F Sarofim, A F Thilly, W G Environ Health Perspect Research Article A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH fraction is higher when it is contacted with cells as a liquid extract than when it is supplied as a coating on soot particles. The substrate particles were found to be nonmutagenic. The rate of transfer of mutagens from the surface of particles, combined with the retention time of respirable aerosol particles, are deemed to define their mutagenic potential. 1991-12 /pmc/articles/PMC1568249/ /pubmed/1820270 Text en
spellingShingle Research Article
Bolsaitis, P P
Feitelberg, A S
Dekermendjian, V
Elliott, J F
Sarofim, A F
Thilly, W G
Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title_full Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title_fullStr Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title_full_unstemmed Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title_short Assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
title_sort assay of mutation induced in human lymphoblastoid cells by combustion-generated soot particles.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568249/
https://www.ncbi.nlm.nih.gov/pubmed/1820270
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