Genotoxicity of glycol ethers.

The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds...

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Detalles Bibliográficos
Autor principal: McGregor, D B
Formato: Texto
Lenguaje:English
Publicado: 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568302/
https://www.ncbi.nlm.nih.gov/pubmed/6541999
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author McGregor, D B
author_facet McGregor, D B
author_sort McGregor, D B
collection PubMed
description The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells. Both EGME and diglyme induced mouse sperm head morphological changes, male rat weak dominant lethal mutations and marked, but reversible, loss of male rat fertility.
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spelling pubmed-15683022006-09-18 Genotoxicity of glycol ethers. McGregor, D B Environ Health Perspect Research Article The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells. Both EGME and diglyme induced mouse sperm head morphological changes, male rat weak dominant lethal mutations and marked, but reversible, loss of male rat fertility. 1984-08 /pmc/articles/PMC1568302/ /pubmed/6541999 Text en
spellingShingle Research Article
McGregor, D B
Genotoxicity of glycol ethers.
title Genotoxicity of glycol ethers.
title_full Genotoxicity of glycol ethers.
title_fullStr Genotoxicity of glycol ethers.
title_full_unstemmed Genotoxicity of glycol ethers.
title_short Genotoxicity of glycol ethers.
title_sort genotoxicity of glycol ethers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568302/
https://www.ncbi.nlm.nih.gov/pubmed/6541999
work_keys_str_mv AT mcgregordb genotoxicityofglycolethers

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