Cargando…

Pulmonary metabolism of foreign compounds: its role in metabolic activation.

The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzym...

Descripción completa

Detalles Bibliográficos
Autor principal: Cohen, G M
Formato: Texto
Lenguaje:English
Publicado: 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568313/
https://www.ncbi.nlm.nih.gov/pubmed/2200668
_version_ 1782129986591784960
author Cohen, G M
author_facet Cohen, G M
author_sort Cohen, G M
collection PubMed
description The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzymes in a heterogeneous tissue, such as the lung, and the balance of metabolic activation and deactivation pathways in any particular cell are key factors in determining the cellular specificity of many pulmonary toxins. Environmental factors such as air pollution, cigarette smoking, and diet markedly affect the pulmonary metabolism of some chemicals and, thereby, possibly affect their toxicity.
format Text
id pubmed-1568313
institution National Center for Biotechnology Information
language English
publishDate 1990
record_format MEDLINE/PubMed
spelling pubmed-15683132006-09-18 Pulmonary metabolism of foreign compounds: its role in metabolic activation. Cohen, G M Environ Health Perspect Research Article The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzymes in a heterogeneous tissue, such as the lung, and the balance of metabolic activation and deactivation pathways in any particular cell are key factors in determining the cellular specificity of many pulmonary toxins. Environmental factors such as air pollution, cigarette smoking, and diet markedly affect the pulmonary metabolism of some chemicals and, thereby, possibly affect their toxicity. 1990-04 /pmc/articles/PMC1568313/ /pubmed/2200668 Text en
spellingShingle Research Article
Cohen, G M
Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title_full Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title_fullStr Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title_full_unstemmed Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title_short Pulmonary metabolism of foreign compounds: its role in metabolic activation.
title_sort pulmonary metabolism of foreign compounds: its role in metabolic activation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568313/
https://www.ncbi.nlm.nih.gov/pubmed/2200668
work_keys_str_mv AT cohengm pulmonarymetabolismofforeigncompoundsitsroleinmetabolicactivation