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Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450.
Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P = S moiety of the thionates, of one or more pulmonary cytochrome P-450 isozymes. The aromatic hydrocarbons p-xylene and pseudocumene also pro...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1990
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568337/ https://www.ncbi.nlm.nih.gov/pubmed/2384072 |
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author | Verschoyle, R D Dinsdale, D |
author_facet | Verschoyle, R D Dinsdale, D |
author_sort | Verschoyle, R D |
collection | PubMed |
description | Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P = S moiety of the thionates, of one or more pulmonary cytochrome P-450 isozymes. The aromatic hydrocarbons p-xylene and pseudocumene also protect against this injury and inhibit some P-450 isozymes, but by a different mechanism. OOS-Trimethylphosphorothionate and p-xylene were compared as protective agents against the effect of OOS-trimethylphosphorothiolate and two other lung toxins ipomeanol and 1-nitronaphthalene that are known to be activated by cytochrome P-450. The effects of these protective compounds, in vivo, on pulmonary cytochrome P-450 activity were also determined. Both compounds inhibited pentoxyresorufin O-deethylase activity, but not ethoxyresorufin O-deethylase. The phosphorothionate was most effective against lung injury caused by the phosphorothiolates and 1-nitronaphthalene, whereas p-xylene was much more effective against ipomeanol. beta-Naphthoflavone, which induces pulmonary ethoxyresorufin O-deethylase activity, did not protect against phosphorothiolate or 1-nitronaphthalene injury, and it was only marginally effective in decreasing the toxicity of ipomeanol. |
format | Text |
id | pubmed-1568337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
record_format | MEDLINE/PubMed |
spelling | pubmed-15683372006-09-18 Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. Verschoyle, R D Dinsdale, D Environ Health Perspect Research Article Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P = S moiety of the thionates, of one or more pulmonary cytochrome P-450 isozymes. The aromatic hydrocarbons p-xylene and pseudocumene also protect against this injury and inhibit some P-450 isozymes, but by a different mechanism. OOS-Trimethylphosphorothionate and p-xylene were compared as protective agents against the effect of OOS-trimethylphosphorothiolate and two other lung toxins ipomeanol and 1-nitronaphthalene that are known to be activated by cytochrome P-450. The effects of these protective compounds, in vivo, on pulmonary cytochrome P-450 activity were also determined. Both compounds inhibited pentoxyresorufin O-deethylase activity, but not ethoxyresorufin O-deethylase. The phosphorothionate was most effective against lung injury caused by the phosphorothiolates and 1-nitronaphthalene, whereas p-xylene was much more effective against ipomeanol. beta-Naphthoflavone, which induces pulmonary ethoxyresorufin O-deethylase activity, did not protect against phosphorothiolate or 1-nitronaphthalene injury, and it was only marginally effective in decreasing the toxicity of ipomeanol. 1990-04 /pmc/articles/PMC1568337/ /pubmed/2384072 Text en |
spellingShingle | Research Article Verschoyle, R D Dinsdale, D Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title | Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title_full | Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title_fullStr | Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title_full_unstemmed | Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title_short | Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450. |
title_sort | protection against chemical-induced lung injury by inhibition of pulmonary cytochrome p-450. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568337/ https://www.ncbi.nlm.nih.gov/pubmed/2384072 |
work_keys_str_mv | AT verschoylerd protectionagainstchemicalinducedlunginjurybyinhibitionofpulmonarycytochromep450 AT dinsdaled protectionagainstchemicalinducedlunginjurybyinhibitionofpulmonarycytochromep450 |