Free-radical production and oxidative reactions of hemoglobin.

Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contr...

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Detalles Bibliográficos
Autor principal: Winterbourn, C C
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568600/
https://www.ncbi.nlm.nih.gov/pubmed/3007097
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author Winterbourn, C C
author_facet Winterbourn, C C
author_sort Winterbourn, C C
collection PubMed
description Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions of various protective agents, are considered.
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spelling pubmed-15686002006-09-18 Free-radical production and oxidative reactions of hemoglobin. Winterbourn, C C Environ Health Perspect Research Article Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions of various protective agents, are considered. 1985-12 /pmc/articles/PMC1568600/ /pubmed/3007097 Text en
spellingShingle Research Article
Winterbourn, C C
Free-radical production and oxidative reactions of hemoglobin.
title Free-radical production and oxidative reactions of hemoglobin.
title_full Free-radical production and oxidative reactions of hemoglobin.
title_fullStr Free-radical production and oxidative reactions of hemoglobin.
title_full_unstemmed Free-radical production and oxidative reactions of hemoglobin.
title_short Free-radical production and oxidative reactions of hemoglobin.
title_sort free-radical production and oxidative reactions of hemoglobin.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568600/
https://www.ncbi.nlm.nih.gov/pubmed/3007097
work_keys_str_mv AT winterbourncc freeradicalproductionandoxidativereactionsofhemoglobin

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