Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.

The spin-trapping method is introduced and discussed. Some chemistry of nitroxides and nitrones is reviewed. Pattern recognition of ESR spectra of nitroxides is outlined. Factors controlling the magnitude of hyperfine splitting constants are mentioned. Methods of assigning spin adducts are listed. R...

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Detalles Bibliográficos
Autores principales: Janzen, E G, Stronks, H J, Dubose, C M, Poyer, J L, McCay, P B
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568620/
https://www.ncbi.nlm.nih.gov/pubmed/3007086
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author Janzen, E G
Stronks, H J
Dubose, C M
Poyer, J L
McCay, P B
author_facet Janzen, E G
Stronks, H J
Dubose, C M
Poyer, J L
McCay, P B
author_sort Janzen, E G
collection PubMed
description The spin-trapping method is introduced and discussed. Some chemistry of nitroxides and nitrones is reviewed. Pattern recognition of ESR spectra of nitroxides is outlined. Factors controlling the magnitude of hyperfine splitting constants are mentioned. Methods of assigning spin adducts are listed. Review articles in the literature are referenced. Results in the electrochemical reduction of halocarbons are presented and some parallels with superoxide chemistry shown. Various speculative reactions are given. The in vitro and in vivo experiments where halocarbon radicals have been detected by spin trapping are reviewed and some new results reported. A comparison for different animals is added.
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spelling pubmed-15686202006-09-18 Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo. Janzen, E G Stronks, H J Dubose, C M Poyer, J L McCay, P B Environ Health Perspect Research Article The spin-trapping method is introduced and discussed. Some chemistry of nitroxides and nitrones is reviewed. Pattern recognition of ESR spectra of nitroxides is outlined. Factors controlling the magnitude of hyperfine splitting constants are mentioned. Methods of assigning spin adducts are listed. Review articles in the literature are referenced. Results in the electrochemical reduction of halocarbons are presented and some parallels with superoxide chemistry shown. Various speculative reactions are given. The in vitro and in vivo experiments where halocarbon radicals have been detected by spin trapping are reviewed and some new results reported. A comparison for different animals is added. 1985-12 /pmc/articles/PMC1568620/ /pubmed/3007086 Text en
spellingShingle Research Article
Janzen, E G
Stronks, H J
Dubose, C M
Poyer, J L
McCay, P B
Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title_full Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title_fullStr Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title_full_unstemmed Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title_short Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
title_sort chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568620/
https://www.ncbi.nlm.nih.gov/pubmed/3007086
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AT stronkshj chemistryandbiologyofspintrappingradicalsassociatedwithhalocarbonmetabolisminvitroandinvivo
AT dubosecm chemistryandbiologyofspintrappingradicalsassociatedwithhalocarbonmetabolisminvitroandinvivo
AT poyerjl chemistryandbiologyofspintrappingradicalsassociatedwithhalocarbonmetabolisminvitroandinvivo
AT mccaypb chemistryandbiologyofspintrappingradicalsassociatedwithhalocarbonmetabolisminvitroandinvivo

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