PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell...

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Detalles Bibliográficos
Autores principales: Trosko, J E, Dawson, B, Chang, C C
Formato: Texto
Lenguaje:English
Publicado: 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568655/
https://www.ncbi.nlm.nih.gov/pubmed/6257504
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author Trosko, J E
Dawson, B
Chang, C C
author_facet Trosko, J E
Dawson, B
Chang, C C
author_sort Trosko, J E
collection PubMed
description Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.
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spelling pubmed-15686552006-09-19 PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter. Trosko, J E Dawson, B Chang, C C Environ Health Perspect Research Article Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter. 1981-01 /pmc/articles/PMC1568655/ /pubmed/6257504 Text en
spellingShingle Research Article
Trosko, J E
Dawson, B
Chang, C C
PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title_full PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title_fullStr PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title_full_unstemmed PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title_short PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
title_sort pbb inhibits metabolic cooperation in chinese hamster cells in vitro: its potential as a tumor promoter.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568655/
https://www.ncbi.nlm.nih.gov/pubmed/6257504
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AT changcc pbbinhibitsmetaboliccooperationinchinesehamstercellsinvitroitspotentialasatumorpromoter

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